PMID- 9737788
OWN - NLM
STAT- MEDLINE
DCOM- 19980925
LR  - 20211203
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 433
IP  - 2
DP  - 1998 Aug
TI  - ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker 
      for Ewing's sarcoma and primitive neuroectodermal tumour.
PG  - 113-7
AB  - ILK (beta1-integrin-linked protein kinase) is a recently identified 59-kDa 
      serine/threonine protein kinase that interacts with the cytoplasmic domain of the 
      beta1-integrin containing four ankyrin-like repeats. We have developed a 
      polyclonal antibody against ILK and explored the ILK immunoreactivity in normal 
      human cells and tissues. ILK was mainly expressed in cardiac muscle and skeletal 
      muscles. Surprisingly, ILK expression was observed in Ewing's sarcoma (ES; 100%), 
      primitive neuroectodermal tumour (PNET; 100%), medulloblastoma (100%), and 
      neuroblastoma (33.3%), whereas other small round cell sarcomas were not stained 
      by the anti-ILK antibody. These results suggest that ILK could be a novel marker 
      for tumours with primitive neural differentiation. Our findings support the 
      notion that ES is a tumour that is closely related to PNET and that both 
      originate from the neuroectoderm. ILK may be a sensitive and specific 
      immunohistochemical marker and useful for the positive identification of ES and 
      PNET in formalin-fixed, paraffin-embedded tissue sections.
FAU - Chung, D H
AU  - Chung DH
AD  - Department of Pathology, Seoul National University College of Medicine, Korea.
FAU - Lee, J I
AU  - Lee JI
FAU - Kook, M C
AU  - Kook MC
FAU - Kim, J R
AU  - Kim JR
FAU - Kim, S H
AU  - Kim SH
FAU - Choi, E Y
AU  - Choi EY
FAU - Park, S H
AU  - Park SH
FAU - Song, H G
AU  - Song HG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.1.- (integrin-linked kinase)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Biomarkers, Tumor/*analysis
MH  - Blotting, Western
MH  - Child
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - *Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neuroectodermal Tumors, Primitive/diagnosis/*enzymology
MH  - Organ Specificity
MH  - Protein Serine-Threonine Kinases/*analysis
MH  - Sarcoma, Ewing/diagnosis/*enzymology
MH  - Sensitivity and Specificity
EDAT- 1998/09/16 00:00
MHDA- 1998/09/16 00:01
CRDT- 1998/09/16 00:00
PHST- 1998/09/16 00:00 [pubmed]
PHST- 1998/09/16 00:01 [medline]
PHST- 1998/09/16 00:00 [entrez]
AID - 10.1007/s004280050225 [doi]
PST - ppublish
SO  - Virchows Arch. 1998 Aug;433(2):113-7. doi: 10.1007/s004280050225.