PMID- 9738722
OWN - NLM
STAT- MEDLINE
DCOM- 19981001
LR  - 20190630
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 133
IP  - 3
DP  - 1998 Sep
TI  - Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and 
      human herpesvirus 6 infections in children.
PG  - 386-9
AB  - OBJECTIVE: To define the clinical and virologic characteristics of primary human 
      herpesvirus 7 (HHV-7) infection and to compare these characteristics with those 
      of primary human herpesvirus 6 (HHV-6) infection. STUDY DESIGN: A prospective 
      convenience sample study of 496 children < or =3 years old. HHV-7 and HHV-6 
      infections were identified by viral isolation. Polymerase chain reaction and 
      serology for HHV-7 and HHV-6 were performed. Clinical and laboratory 
      characteristics of patients were obtained from medical records and follow-up 
      interviews. RESULTS: Children with primary HHV-7 infection (n = 8) were 
      identified and compared with children with primary HHV-6 infection (n = 29) 
      detected during the same time period. All children were febrile (mean temperature 
      39.8 degrees C) with no difference in the degree of fever, frequency of rash, or 
      gastrointestinal complications between the groups. The median age of children 
      with primary HHV-7 infection was 26 months, significantly older than that of 
      children with primary HHV-6 infection (median, 9 months). Children with primary 
      HHV-7 infection were also more likely than those with primary HHV-6 infection to 
      have seizures associated with the illness (P = .004). CONCLUSION: Primary 
      infection with HHV-7 can cause a highly febrile illness in childhood, complicated 
      by seizures. The serologic diagnosis of primary HHV-6 and HHV-7 infections may be 
      confounded by cross-reacting antibodies.
FAU - Caserta, M T
AU  - Caserta MT
AD  - Department of Pediatrics and Medicine, Children's Hospital at Strong, University 
      of Rochester School of Medicine and Dentistry, New York, USA.
FAU - Hall, C B
AU  - Hall CB
FAU - Schnabel, K
AU  - Schnabel K
FAU - Long, C E
AU  - Long CE
FAU - D'Heron, N
AU  - D'Heron N
LA  - eng
GR  - R01 A 133020-02/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Age Factors
MH  - Antibodies, Viral/analysis
MH  - Child, Preschool
MH  - Cross Reactions
MH  - Diarrhea/physiopathology
MH  - Exanthema/physiopathology
MH  - Fever/physiopathology
MH  - Follow-Up Studies
MH  - Herpesviridae Infections/diagnosis/immunology/*physiopathology
MH  - *Herpesvirus 6, Human/genetics/immunology/isolation & purification
MH  - *Herpesvirus 7, Human/genetics/immunology/isolation & purification
MH  - Humans
MH  - Infant
MH  - Interviews as Topic
MH  - Polymerase Chain Reaction
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Seizures/physiopathology
MH  - Vomiting/physiopathology
EDAT- 1998/09/17 00:00
MHDA- 1998/09/17 00:01
CRDT- 1998/09/17 00:00
PHST- 1998/09/17 00:00 [pubmed]
PHST- 1998/09/17 00:01 [medline]
PHST- 1998/09/17 00:00 [entrez]
AID - S0022-3476(98)70275-6 [pii]
AID - 10.1016/s0022-3476(98)70275-6 [doi]
PST - ppublish
SO  - J Pediatr. 1998 Sep;133(3):386-9. doi: 10.1016/s0022-3476(98)70275-6.