PMID- 9739014
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20191024
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 23
IP  - 2
DP  - 1998 Oct
TI  - Molecular cytogenetic delineation of 17q translocation breakpoints in 
      neuroblastoma cell lines.
PG  - 116-22
AB  - It has recently been recognized that unbalanced translocations resulting in the 
      gain of material from 17q are the most common chromosomal changes in 
      neuroblastoma. These rearrangements are associated with established indicators of 
      bad prognosis and poor patient survival. We have used 13 fluorescence in situ 
      hybridization (FISH) probes to map 12 translocation breakpoints on 17q in 10 
      neuroblastoma cell lines, identifying at least seven different breakpoints, all 
      localized within the proximal half of 17q (268-369 cR, 53-68 cM). These results 
      suggest that the dosage of a gene, or genes, in 17q22-qter is responsible for the 
      clinical effects of 17q gain, rather than the disruption of a specific gene. This 
      region contains two genes, nm23-H1 and NGFR, already implicated in neuroblastoma 
      biology.
FAU - Lastowska, M
AU  - Lastowska M
AD  - Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom.
FAU - Van Roy, N
AU  - Van Roy N
FAU - Bown, N
AU  - Bown N
FAU - Speleman, F
AU  - Speleman F
FAU - Lunec, J
AU  - Lunec J
FAU - Strachan, T
AU  - Strachan T
FAU - Pearson, A D
AU  - Pearson AD
FAU - Jackson, M S
AU  - Jackson MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chromosome Breakage/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Metaphase
MH  - Neuroblastoma/*genetics/pathology
MH  - Translocation, Genetic/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1998/09/17 02:03
MHDA- 2000/06/20 09:00
CRDT- 1998/09/17 02:03
PHST- 1998/09/17 02:03 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/09/17 02:03 [entrez]
AID - 10.1002/(SICI)1098-2264(199810)23:2<116::AID-GCC4>3.0.CO;2-5 [pii]
AID - 10.1002/(sici)1098-2264(199810)23:2<116::aid-gcc4>3.0.co;2-5 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1998 Oct;23(2):116-22. doi: 
      10.1002/(sici)1098-2264(199810)23:2<116::aid-gcc4>3.0.co;2-5.