PMID- 9741396
OWN - NLM
STAT- MEDLINE
DCOM- 19981210
LR  - 20190724
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 159
IP  - 2
DP  - 1998 Aug 14
TI  - Sustained release dosage of thyrotropin-releasing hormone improves experimental 
      Japanese encephalitis virus-induced parkinsonism in rats.
PG  - 135-9
AB  - Thyrotropin-releasing hormone (TRH) has been reported to have some possibilities 
      toward the treatment of affective CNS disorders. However, long term treatments 
      with daily injections are often required. Effects of TRH-SR (sustained release 
      microspheres of TRH) which is encapsulated in copoly (dl-lactic/glycolic acid) 
      using an in-water drying method were investigated in experimental Japanese 
      encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole 
      test and high performance liquid chromatography (HPLC) with an electrochemical 
      detector (ECD). We have already reported that in adult Fischer rats killed 12 
      weeks after infection with JEV at the age of 13 days a marked decrease of 
      tyrosine hydroxylase-positive neurons was found in the bilateral substantia 
      nigra. TRH-SR (3 mg/kg per 2 weeks, 4 times injections, subcutaneous [s.c.]) 
      improved bradykinesia observed in the JEV-induced parkinsonism rats. Dopamine 
      (DA) concentrations in the JEV-infected rats were profoundly reduced in the 
      striatum as compared with controls. TRH-SR (3 mg/kg, once, s.c.) increased DA in 
      the striatum 7 days after the injection. Although the pathomechanism of 
      post-encephalitic parkinsonism is different from that of Parkinson's disease and 
      TRH possesses a variety of CNS effects as well, these results suggest that TRH-SR 
      play a possible role in the treatment of Parkinson's disease in addition to 
      post-encephalitic parkinsonism as a supportive drug of L-DOPA.
FAU - Ogata, A
AU  - Ogata A
AD  - Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan. 
      a-ogata@med.hokudai.ac.jp
FAU - Nagashima, K
AU  - Nagashima K
FAU - Yasui, K
AU  - Yasui K
FAU - Matsuura, T
AU  - Matsuura T
FAU - Tashiro, K
AU  - Tashiro K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Delayed-Action Preparations)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Delayed-Action Preparations
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Encephalitis Viruses, Japanese/*physiology
MH  - Parkinson Disease, Secondary/*drug therapy/metabolism/virology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Thyrotropin-Releasing Hormone/*administration & dosage
EDAT- 1998/09/19 00:00
MHDA- 1998/09/19 00:01
CRDT- 1998/09/19 00:00
PHST- 1998/09/19 00:00 [pubmed]
PHST- 1998/09/19 00:01 [medline]
PHST- 1998/09/19 00:00 [entrez]
AID - S0022510X98001506 [pii]
AID - 10.1016/s0022-510x(98)00150-6 [doi]
PST - ppublish
SO  - J Neurol Sci. 1998 Aug 14;159(2):135-9. doi: 10.1016/s0022-510x(98)00150-6.