PMID- 9743373
OWN - NLM
STAT- MEDLINE
DCOM- 19981006
LR  - 20131121
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 161
IP  - 6
DP  - 1998 Sep 15
TI  - Differential regulation of monocyte matrix metalloproteinase and TIMP-1 
      production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through 
      prostaglandin-dependent and -independent mechanisms.
PG  - 3071-6
AB  - Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) produced 
      by monocytes are believed to be involved in the migration of these cells through 
      the basement membrane and the ensuing destruction of connective tissue in chronic 
      inflammatory lesions. Because monocytes encounter a variety of cytokines at these 
      sites, we examined the effect of cytokines either alone or in combination on the 
      production of monocyte MMPs and TIMP-1. TNF-alpha, granulocyte-macrophage-CSF 
      (GM-CSF), or IL-1 beta when added individually enhanced the endogenous levels of 
      92-kDa gelatinase (MMP-9) and TIMP-1 but failed to induce interstitial 
      collagenase (MMP-1). However, GM-CSF, when added with either TNF-alpha or IL-1 
      beta, induced MMP-1 and synergistically enhanced MMP-9 and TIMP-1. Th2 cytokines, 
      such as IL-4, inhibited the induction of MMPs and TIMP-1 by TNF-alpha, GM-CSF, 
      and IL-1. Cytokine stimulation of MMP-1 was due, at least in part, to an increase 
      in the release of arachidonic acid and PG E2 (PGE2), because inhibition of MMP-1 
      by indomethacin could be reversed by exogenous PGE2. In contrast to MMP-1, 
      cytokine stimulation of MMP-9 and TIMP-1 was unaffected by indomethacin. The 
      PGE2-independent induction of monocyte MMP-9 and TIMP-1 by these cytokines 
      differed from stimulation of MMP-9 and TIMP-1 by LPS, which is in large part 
      PG-dependent. In addition, LPS stimulated higher levels of MMP-1 whereas 
      cytokines induced higher levels of MMP-9 and TIMP-1. This is the first 
      demonstration that monocyte MMP-1 can be induced by cytokines and that MMP-1, 
      MMP-9, and TIMP-1 are differentially regulated by cytokines through PG-dependent 
      and -independent mechanisms.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Immunopathology Section, National Institute of Dental Research, National 
      Institutes of Health, Bethesda, MD 20892-4352, USA.
FAU - McCluskey, K
AU  - McCluskey K
FAU - Fujii, K
AU  - Fujii K
FAU - Wahl, L M
AU  - Wahl LM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Cytokines)
RN  - 0 (Drug Combinations)
RN  - 0 (Interleukin-1)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Prostaglandins)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 63X7MBT2LQ (Bucladesine)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Arachidonic Acid/metabolism
MH  - Bucladesine/pharmacology
MH  - Collagenases/biosynthesis
MH  - Cytokines/*pharmacology
MH  - Dinoprostone/biosynthesis/pharmacology
MH  - Drug Combinations
MH  - Enzyme Induction/drug effects
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
MH  - Humans
MH  - Indomethacin/pharmacology
MH  - Interleukin-1/pharmacology
MH  - Interleukin-4/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Matrix Metalloproteinase 1
MH  - Matrix Metalloproteinase 9
MH  - Metalloendopeptidases/*biosynthesis/drug effects
MH  - Monocytes/drug effects/*enzymology
MH  - Prostaglandins/*physiology
MH  - Tissue Inhibitor of Metalloproteinase-1/*biosynthesis
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 1998/09/22 00:00
MHDA- 1998/09/22 00:01
CRDT- 1998/09/22 00:00
PHST- 1998/09/22 00:00 [pubmed]
PHST- 1998/09/22 00:01 [medline]
PHST- 1998/09/22 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1998 Sep 15;161(6):3071-6.