PMID- 9747029
OWN - NLM
STAT- MEDLINE
DCOM- 19981022
LR  - 20220409
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 43
IP  - 3
DP  - 1998
TI  - Expression and chromosomal localization of KIAA0369, a putative kinase 
      structurally related to Doublecortin.
PG  - 169-77
AB  - Neuropathy in vertebrates can be a consequence of failure of genes involved in 
      the nervous system to be expressed at the correct times and levels during 
      embryonic life. Recently, a brain specific gene, Doublecortin, was cloned and was 
      shown to have mutations in X-linked lissencephaly and double cortex syndrome. 
      KIAA0369 is a putative kinase that is structurally related to Doublecortin. We 
      compared the expression of KIAA0369 with that of Doublecortin, both of which were 
      expressed specifically or predominantly in fetal brain among 20 different tissues 
      examined. The deduced products of both genes contain a unique domain (the 
      Doublecortin [DC] domain), but KIAA0369 also contains a calmodulin-dependent 
      kinase (CaM kinase)-like domain following the DC domain. We found at least four 
      splicing variants of KIAA0369: KIAA0369-AS (type A, short version), KIAA0369-AL 
      (type A, long version), KIAA0369-BS (type B, short version), and KIAA0369-BL 
      (type B, long version). KIAA0369-B, which lacked the DC domain and maintained the 
      kinase domain, was expressed in adult as well as fetal brain, but the variants 
      that included the DC domain, KIAA0369-A, were expressed predominantly in fetal 
      brain. These results suggest that the DC domain plays an important role in the 
      development of the nervous system. In the adult brain, KIAA0369 was expressed in 
      all 15 different regions examined, more intensely in cerebral cortex, occipital 
      pole, frontal lobe, amygdala, and hippocampus, and less intensely in corpus 
      callosum and thalamus. The murine homologs of Doublecortin and KIAA0369 were not 
      detectable in 7-day mouse embryos, but both genes were expressed extensively in 
      11-day embryos. Human KIAA0369 was mapped by fluorescence in situ hybridization 
      (FISH) to chromosome 13q13-q14.1. The presence of genes related to neuropathy has 
      been reported in this locus.
FAU - Omori, Y
AU  - Omori Y
AD  - Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
FAU - Suzuki, M
AU  - Suzuki M
FAU - Ozaki, K
AU  - Ozaki K
FAU - Harada, Y
AU  - Harada Y
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Takahashi, E
AU  - Takahashi E
FAU - Fujiwara, T
AU  - Fujiwara T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Dcx protein, mouse)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Nuclear Localization Signals)
RN  - EC 2.7.1.11 (DCLK1 protein, human)
RN  - EC 2.7.1.11 (Doublecortin-Like Kinases)
RN  - EC 2.7.11.1 (Dclk1 protein, mouse)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Adult
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*genetics
MH  - Cerebral Cortex/abnormalities
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Cloning, Molecular
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Doublecortin-Like Kinases
MH  - Fetus
MH  - Gene Expression
MH  - Genetic Linkage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intracellular Signaling Peptides and Proteins
MH  - *Microtubule-Associated Proteins
MH  - Molecular Sequence Data
MH  - *Nerve Tissue Proteins
MH  - Nervous System Malformations/*genetics
MH  - Neuropeptides/genetics
MH  - Nuclear Localization Signals
MH  - *Protein Serine-Threonine Kinases
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - X Chromosome
EDAT- 1998/09/25 00:00
MHDA- 1998/09/25 00:01
CRDT- 1998/09/25 00:00
PHST- 1998/09/25 00:00 [pubmed]
PHST- 1998/09/25 00:01 [medline]
PHST- 1998/09/25 00:00 [entrez]
AID - 10.1007/s100380050063 [doi]
PST - ppublish
SO  - J Hum Genet. 1998;43(3):169-77. doi: 10.1007/s100380050063.