PMID- 9747370
OWN - NLM
STAT- MEDLINE
DCOM- 19981008
LR  - 20190704
IS  - 0007-0963 (Print)
IS  - 0007-0963 (Linking)
VI  - 138
IP  - 6
DP  - 1998 Jun
TI  - The significance of the 'dust-like particles' pattern of immunofluorescence. A 
      study of 66 cases.
PG  - 1039-42
AB  - Subacute cutaneous lupus erythematosus (SCLE) is a marker of a unique subset of 
      lupus erythematosus patients. A 'dust-like particles' direct immunofluorescence 
      (DIF) staining pattern, which consists of fine granular particles of 
      immunoglobulin(s) scattered through the epidermis and the cellular infiltrates of 
      the dermis, was reported to be specific for SCLE. In this study, we assessed the 
      real specificity of this staining pattern, which had not yet been evaluated. We 
      systematically searched for the dust-like particles staining pattern among the 
      4374 skin biopsy specimens submitted for direct cutaneous immunofluorescence 
      during a 7-year period (1989-96). The corresponding patient records were 
      reviewed. Dust-like particles were observed in 66 samples originating from 60 
      patients. Only 53% of the patients had SCLE. The remaining patients had systemic 
      lupus erythematosus with visceral involvement (17%), discoid lupus erythematosus 
      (3%), mixed connective tissue disease (2%). Sjogren syndrome (2%) and other 
      diseases. Eighty-five per cent of the patients had connective tissue disease. 
      Seventy-seven per cent of the patients were positive for antinuclear antibodies, 
      but only 36% were positive for anti-Ro (SSA) antibodies. This study shows that 
      the dust-like particles staining pattern is not specific for SCLE, but is highly 
      suggestive of connective tissue disease. The nature of the antigen responsible 
      for the immunoglobulin deposition and the prognostic significance of this DIF 
      pattern remain to be established.
FAU - Lipsker, D
AU  - Lipsker D
AD  - Clinique Dermatologique des Hopitaux Universitaires de Strasbourg, Strasbourg, 
      France.
FAU - Di Cesare, M P
AU  - Di Cesare MP
FAU - Cribier, B
AU  - Cribier B
FAU - Grosshans, E
AU  - Grosshans E
FAU - Heid, E
AU  - Heid E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (Antibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Antibodies/analysis
MH  - Fluorescent Antibody Technique, Direct
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Lupus Erythematosus, Cutaneous/*diagnosis/immunology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Skin/immunology
EDAT- 1998/09/25 00:00
MHDA- 1998/09/25 00:01
CRDT- 1998/09/25 00:00
PHST- 1998/09/25 00:00 [pubmed]
PHST- 1998/09/25 00:01 [medline]
PHST- 1998/09/25 00:00 [entrez]
AID - 10.1046/j.1365-2133.1998.02275.x [doi]
PST - ppublish
SO  - Br J Dermatol. 1998 Jun;138(6):1039-42. doi: 10.1046/j.1365-2133.1998.02275.x.