PMID- 9748058
OWN - NLM
STAT- MEDLINE
DCOM- 19981020
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 51
IP  - 3
DP  - 1998 Sep
TI  - The value of interphase cytogenetics in cytology for the diagnosis of 
      leptomeningeal metastases.
PG  - 906-8
AB  - We studied the use of fluorescence in situ hybridization (FISH) in CSF to enhance 
      the diagnostic yield for the detection of malignancy on the first lumbar puncture 
      in patients clinically suspected of having leptomeningeal metastases (LMM). 
      Although repeated lumbar punctures were still needed in some patients, the use of 
      FISH did speed up the diagnosis in approximately one-third of the patients 
      clinically suspected of having LMM with atypical cells at first cytology. This 
      eliminates the need for repeated lumbar punctures in these patients and enables 
      an earlier start of treatment.
FAU - van Oostenbrugge, R J
AU  - van Oostenbrugge RJ
AD  - Department of Neurology, University Hospital Maastricht, The Netherlands.
FAU - Hopman, A H
AU  - Hopman AH
FAU - Arends, J W
AU  - Arends JW
FAU - Ramaekers, F C
AU  - Ramaekers FC
FAU - Twijnstra, A
AU  - Twijnstra A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Cerebrospinal Fluid/*cytology
MH  - Cytogenetics/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Meningeal Neoplasms/cerebrospinal fluid/*diagnosis/genetics/*secondary
MH  - Predictive Value of Tests
EDAT- 1998/09/25 00:00
MHDA- 1998/09/25 00:01
CRDT- 1998/09/25 00:00
PHST- 1998/09/25 00:00 [pubmed]
PHST- 1998/09/25 00:01 [medline]
PHST- 1998/09/25 00:00 [entrez]
AID - 10.1212/wnl.51.3.906 [doi]
PST - ppublish
SO  - Neurology. 1998 Sep;51(3):906-8. doi: 10.1212/wnl.51.3.906.