PMID- 9748101
OWN - NLM
STAT- MEDLINE
DCOM- 19981209
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 64
IP  - 3
DP  - 1998 Jun 1
TI  - Neural substrates for leptin and neuropeptide Y (NPY) interaction: hypothalamic 
      sites associated with inhibition of NPY-induced food intake.
PG  - 331-8
AB  - Intracerebroventricular (i.c.v.) injection of leptin, the adipocyte hormone, 
      inhibits neuropeptide Y (NPY)-induced feeding in the rat. To identify the neural 
      substrate for leptin and NPY interaction in the hypothalamus, we evaluated the 
      expression of c-fos-like immunoreactivity (FLI), an early marker of neuronal 
      activation, in response to icv administration of leptin, NPY and leptin plus NPY. 
      As expected, leptin significantly decreased NPY-induced feeding in leptin plus 
      NPY-treated rats. A comparative evaluation of the number of FLI-positive neurons 
      in hypothalamic sites showed that both leptin and NPY activated FLI in the 
      parvocellular subdivision of the paraventricular nucleus (pPVN), dorsomedial 
      nucleus (DMN) and ventromedial nucleus (VMN). NPY also augmented the FLI response 
      in the magnocellular PVN (mPVN) and supraoptic nucleus (SON), two sites where 
      leptin alone was ineffective. Combined leptin and NPY treatment significantly 
      decreased the number of FLI-positive neurons in the magnocellular PVN but 
      increased their number in the dorsomedial nucleus as compared to the number of 
      FLI-expressing neurons in these sites after NPY and leptin alone. Because there 
      is morphologic evidence of a link between magnocellular PVN and dorsomedial 
      nucleus, these results suggest the functional involvement of leptin plus NPY 
      responsive elements in these sites in reduction of NPY-induced feeding by leptin.
FAU - Yokosuka, M
AU  - Yokosuka M
AD  - Department of Neuroscience, University of Florida College of Medicine, 
      Gainesville 32610, USA.
FAU - Xu, B
AU  - Xu B
FAU - Pu, S
AU  - Pu S
FAU - Kalra, P S
AU  - Kalra PS
FAU - Kalra, S P
AU  - Kalra SP
LA  - eng
GR  - DK37273/DK/NIDDK NIH HHS/United States
GR  - NS32727/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Appetite Stimulants)
RN  - 0 (Leptin)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Appetite Stimulants/*pharmacology
MH  - Eating/drug effects
MH  - Hypothalamus/anatomy & histology/metabolism/*physiology
MH  - Immunohistochemistry
MH  - Leptin
MH  - Male
MH  - Neuropeptide Y/*pharmacology/*physiology
MH  - Proteins/*physiology
MH  - Proto-Oncogene Proteins c-fos/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1998/09/25 00:00
MHDA- 1998/09/25 00:01
CRDT- 1998/09/25 00:00
PHST- 1998/09/25 00:00 [pubmed]
PHST- 1998/09/25 00:01 [medline]
PHST- 1998/09/25 00:00 [entrez]
AID - S0031-9384(98)00065-1 [pii]
AID - 10.1016/s0031-9384(98)00065-1 [doi]
PST - ppublish
SO  - Physiol Behav. 1998 Jun 1;64(3):331-8. doi: 10.1016/s0031-9384(98)00065-1.