PMID- 9748522
OWN - NLM
STAT- MEDLINE
DCOM- 19981224
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 802
IP  - 1-2
DP  - 1998 Aug 17
TI  - Functional integration among 5-hydroxytryptamine receptor families in the control 
      of female rat sexual behavior.
PG  - 98-103
AB  - Serotonin (5-HT) receptor interaction in the control of female rat lordosis 
      behavior was examined. Ovariectomized rats, with bilateral implants in the 
      ventromedial nucleus of the hypothalamus (VMN), were hormonally primed with 25 
      micrograms estradiol benzoate and 500 micrograms progesterone. Rats were infused 
      with the 5-HT3 receptor antagonist, 3-tropanyl-indole-3 carbonylate (tropisetron; 
      500 ng), or were coinfused with the 5-HT3 receptor antagonist and the 5-HT2A/2C 
      receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI; 500, 1500, 
      or 2000 ng). Additional ovariectomized, hormone-primed rats received bilateral 
      VMN infusions with the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) 
      tetralin (8-OH-DPAT; 200 ng), or were coinfused with the 5-HT1A receptor agonist 
      and the 5-HT3 receptor agonist, m-chlorophenyl-biguanide (mCPBG; 250, 500, or 
      1000 ng). Lordosis behavior was observed prior to VMN infusion, during the 
      infusion and for 30 consecutive minutes thereafter. Tropisetron reduced the 
      lordosis to mount (L/M) ratio in every animal investigated but the decline was 
      attenuated by coinfusion with DOI. Similarly, the L/M ratio declined following 
      infusion with 8-OH-DPAT and the decline was dose-dependently reduced by 
      coinfusion with mCPBG. Only the 5-HT3 receptor agonist altered the quality of the 
      lordosis reflex. These studies provide evidence that the effects of 5-HT on 
      female rat lordosis behavior involve the integrated activity of at least 3 
      different 5-HT receptor families.
FAU - Maswood, N
AU  - Maswood N
AD  - Department of Biology, Texas Woman's University, Denton 76204, USA.
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amphetamines)
RN  - 0 (Biguanides)
RN  - 0 (Drug Combinations)
RN  - 0 (Indoles)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 6I819NIK1W (Tropisetron)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - 910A4X901V (1-(3-chlorophenyl)biguanide)
RN  - OOM10GW9UE (4-iodo-2,5-dimethoxyphenylisopropylamine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Amphetamines/pharmacology
MH  - Animals
MH  - Biguanides/pharmacology
MH  - Drug Combinations
MH  - Female
MH  - Indoles/pharmacology
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/*physiology
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Sexual Behavior, Animal/*physiology
MH  - Tropisetron
EDAT- 1998/09/28 00:00
MHDA- 1998/09/28 00:01
CRDT- 1998/09/28 00:00
PHST- 1998/09/28 00:00 [pubmed]
PHST- 1998/09/28 00:01 [medline]
PHST- 1998/09/28 00:00 [entrez]
AID - S0006-8993(98)00554-X [pii]
AID - 10.1016/s0006-8993(98)00554-x [doi]
PST - ppublish
SO  - Brain Res. 1998 Aug 17;802(1-2):98-103. doi: 10.1016/s0006-8993(98)00554-x.