PMID- 9748553
OWN - NLM
STAT- MEDLINE
DCOM- 19981224
LR  - 20231213
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 802
IP  - 1-2
DP  - 1998 Aug 17
TI  - Studies on the interaction between 1,2,3,4-tetrahydro-beta-carboline and 
      cigarette smoke: a potential mechanism of neuroprotection for Parkinson's 
      disease.
PG  - 155-62
AB  - 1,2,3,4-Tetrahydro-beta-carboline (TH beta C) is an endogenous or environmental 
      neurotoxic factor putatively involved in the development of Parkinson's disease 
      (PD). As part of our efforts to characterize the mechanism of the reported 
      protection of smoking against PD, we have examined the interaction between TH 
      beta C and cigarette smoke. We found that TH beta C reacts in vitro and under 
      physiological conditions with some components of cigarette smoke to form 
      N2-(cyanomethyl)-TH beta C (CM-TH beta C), N2-(gamma-cyanoethyl)-TH beta C (CE-TH 
      beta C), N2-(1'-cyanopropyl)-TH beta C (CP-TH beta C), N2-(1'-cyanobutyl)-TH beta 
      C (CB-TH beta C) and N2-formyl-TH beta C (F-TH beta C). Significant differences 
      in the recovery of some of these TH beta C-derivatives were obtained for Burley 
      and Bright tobacco. Several of the reported compounds showed reversible and 
      competitive MAO-A inhibitory properties. The detection of some of these compounds 
      in rat brain after chronic administration of TH beta C and a solution of 
      cigarette smoke proved that the reported interactions also occur in vivo. These 
      results are discussed as a potential mechanism of neuroprotection in the 
      development of PD.
FAU - Soto-Otero, R
AU  - Soto-Otero R
AD  - Department of Biochemistry and Molecular Biology, Faculty of Medicine, 
      Universidad de Santiago de Compostela, Spain. bnsoto@uscmail.usc.es
FAU - Mendez-Alvarez, E
AU  - Mendez-Alvarez E
FAU - Riguera-Vega, R
AU  - Riguera-Vega R
FAU - Quinoa-Cabana, E
AU  - Quinoa-Cabana E
FAU - Sanchez-Sellero, I
AU  - Sanchez-Sellero I
FAU - Lopez-Rivadulla Lamas, M
AU  - Lopez-Rivadulla Lamas M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Carbolines)
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Smoke)
RN  - 0 (Solutions)
RN  - 65027TMI0H (tryptoline)
SB  - IM
MH  - Animals
MH  - Brain/enzymology
MH  - Carbolines/analysis/chemistry/*pharmacology
MH  - Drug Interactions
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Male
MH  - Monoamine Oxidase Inhibitors/pharmacology
MH  - Neuroprotective Agents/pharmacology
MH  - Parkinson Disease/prevention & control
MH  - *Plants, Toxic
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Smoke
MH  - Solutions/chemistry/pharmacology
MH  - *Nicotiana
EDAT- 1998/09/28 00:00
MHDA- 1998/09/28 00:01
CRDT- 1998/09/28 00:00
PHST- 1998/09/28 00:00 [pubmed]
PHST- 1998/09/28 00:01 [medline]
PHST- 1998/09/28 00:00 [entrez]
AID - S0006-8993(98)00538-1 [pii]
AID - 10.1016/s0006-8993(98)00538-1 [doi]
PST - ppublish
SO  - Brain Res. 1998 Aug 17;802(1-2):155-62. doi: 10.1016/s0006-8993(98)00538-1.