PMID- 9749608
OWN - NLM
STAT- MEDLINE
DCOM- 19981008
LR  - 20061115
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 44
IP  - 3
DP  - 1998 Sep
TI  - Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear 
      cells from multiple sclerosis patients.
PG  - 391-4
AB  - Several studies have suggested an association between human herpesvirus 6 (HHV-6) 
      infection and multiple sclerosis. As HHV-6 is predominantly a T-cell tropic 
      virus, we examined the frequency of detection of HHV-6 genome in peripheral blood 
      mononuclear cells from relapsing-remitting (n = 32) and chronic progressive (n = 
      14) patients and from healthy (n = 17) and neurological (n = 7) controls. Two 
      sensitive polymerase chain reaction assays were used to target different regions 
      within the HHV-6 genome. Depending on the polymerase chain reaction assay used, 
      the detection of HHV-6 genome ranged from 11.7 to 23.5% (controls), 3.1 to 23.0% 
      (relapsing-remitting), and 14.2 to 28.5% (chronic progressive). Although these 
      observations do not exclude a pathogenic role for HHV-6 in multiple sclerosis, 
      they indicate a lack of correlation between HHV-6 infection of peripheral blood 
      mononuclear cells and the development of multiple sclerosis.
FAU - Mayne, M
AU  - Mayne M
AD  - Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
FAU - Krishnan, J
AU  - Krishnan J
FAU - Metz, L
AU  - Metz L
FAU - Nath, A
AU  - Nath A
FAU - Auty, A
AU  - Auty A
FAU - Sahai, B M
AU  - Sahai BM
FAU - Power, C
AU  - Power C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - DNA, Viral/*blood
MH  - Female
MH  - Herpesviridae Infections/blood/genetics
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Leukocytes, Mononuclear/virology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*blood/etiology/*virology
MH  - Nucleic Acid Hybridization
MH  - Polymerase Chain Reaction
EDAT- 1998/09/28 00:00
MHDA- 1998/09/28 00:01
CRDT- 1998/09/28 00:00
PHST- 1998/09/28 00:00 [pubmed]
PHST- 1998/09/28 00:01 [medline]
PHST- 1998/09/28 00:00 [entrez]
AID - 10.1002/ana.410440317 [doi]
PST - ppublish
SO  - Ann Neurol. 1998 Sep;44(3):391-4. doi: 10.1002/ana.410440317.