PMID- 9749934
OWN - NLM
STAT- MEDLINE
DCOM- 19981118
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 77
IP  - 4
DP  - 1998 Aug
TI  - Intrahepatic flow disturbance as detected by in vivo acridine orange staining in 
      endothelin-1-treated and cirrhotic rats.
PG  - 315-8
AB  - Intrahepatic flow in rats was examined by systemic acridine orange (AO) labeling 
      and succeeding microscopic observations of post-fixed livers. In controls, all 
      periportal areas were stained evenly throughout the liver mass, and the staining 
      often branched between the liver lobules in a acinous fashion. Intraportal 
      endothelin-1 infusion caused a marked heterogenous staining; strong staining 
      around large portal vein branches in the central portion of the liver, but much 
      less in the periphery. Cirrhotic livers exhibited overall weaker staining 
      intensity with no accentuation in periportal areas and restricted radial staining 
      within pseudo-lobules. AO infusion may help detect hepatic flow disturbance in 
      vivo.
FAU - Masuda, Y
AU  - Masuda Y
AD  - Division of Toxicology, Niigata College of Pharmacy, Japan.
FAU - Oguma, T
AU  - Oguma T
FAU - Kaneko, H
AU  - Kaneko H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Endothelin-1)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - F30N4O6XVV (Acridine Orange)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - *Acridine Orange
MH  - Animals
MH  - Carbon Tetrachloride
MH  - Endothelin-1/*pharmacology
MH  - Femoral Vein
MH  - Liver/*blood supply/drug effects/physiopathology
MH  - Liver Circulation/*drug effects/*physiology
MH  - Liver Cirrhosis, Experimental/chemically induced/*physiopathology
MH  - Male
MH  - Microcirculation/drug effects/pathology/physiopathology
MH  - Microscopy, Fluorescence
MH  - Phenobarbital
MH  - Portal Pressure/drug effects/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1998/09/28 00:00
MHDA- 1998/09/28 00:01
CRDT- 1998/09/28 00:00
PHST- 1998/09/28 00:00 [pubmed]
PHST- 1998/09/28 00:01 [medline]
PHST- 1998/09/28 00:00 [entrez]
AID - 10.1254/jjp.77.315 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1998 Aug;77(4):315-8. doi: 10.1254/jjp.77.315.