PMID- 9751260
OWN - NLM
STAT- MEDLINE
DCOM- 19981001
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 130
IP  - 1-2
DP  - 1998 Aug 14
TI  - Interstitial and large chromosome 1p deletion occurs in localized and 
      disseminated neuroblastomas and predicts an unfavourable outcome.
PG  - 83-92
AB  - We studied chromosome 1p loss of heterozygosity (1p-LOH) in 53 neuroblastomas 
      (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also 
      assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on 
      interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 
      23-50%) NBs. We detected interstitial and large deletion in both localized and 
      disseminated tumours and in one tumour of a patient at stage 4S. Allelic loss was 
      frequently observed in 1p36 and 1p32 regions. In patients older than 1 year of 
      age (53 versus 13%, P < 0.002) we detected significant chromosome 1p deletion and 
      it was associated with MYCN amplification (P = 0.001). Overall survival (OS) 
      analysis showed that 1p-LOH is predictive of a poor outcome (odds ratio 16.5, 95% 
      CI 5.4-50.9%); therefore, 1p-LOH should be regarded as an additional tumour 
      progression marker in neuroblastoma.
FAU - Iolascon, A
AU  - Iolascon A
AD  - Department of Biomedicine of Evolutive Age, University of Bari, Genova, Italy.
FAU - Lo Cunsolo, C
AU  - Lo Cunsolo C
FAU - Giordani, L
AU  - Giordani L
FAU - Cusano, R
AU  - Cusano R
FAU - Mazzocco, K
AU  - Mazzocco K
FAU - Boumgartner, M
AU  - Boumgartner M
FAU - Ghisellini, P
AU  - Ghisellini P
FAU - Faienza, M F
AU  - Faienza MF
FAU - Boni, L
AU  - Boni L
FAU - De Bernardi, B
AU  - De Bernardi B
FAU - Conte, M
AU  - Conte M
FAU - Romeo, G
AU  - Romeo G
FAU - Tonini, G P
AU  - Tonini GP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Gene Amplification
MH  - *Gene Deletion
MH  - Genes, myc/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - *Loss of Heterozygosity
MH  - Neuroblastoma/*genetics/pathology
MH  - Prognosis
MH  - Survival Analysis
EDAT- 1998/09/29 00:00
MHDA- 1998/09/29 00:01
CRDT- 1998/09/29 00:00
PHST- 1998/09/29 00:00 [pubmed]
PHST- 1998/09/29 00:01 [medline]
PHST- 1998/09/29 00:00 [entrez]
AID - S0304-3835(98)00122-0 [pii]
AID - 10.1016/s0304-3835(98)00122-0 [doi]
PST - ppublish
SO  - Cancer Lett. 1998 Aug 14;130(1-2):83-92. doi: 10.1016/s0304-3835(98)00122-0.