PMID- 9751473
OWN - NLM
STAT- MEDLINE
DCOM- 19981006
LR  - 20190909
IS  - 0300-9742 (Print)
IS  - 0300-9742 (Linking)
VI  - 27
IP  - 4
DP  - 1998
TI  - Suboptimal clinical response to anti-tumor necrosis factor alpha (TNFalpha) 
      antibody therapy in a patient with severe rheumatoid arthritis and 
      lymphadenopathy.
PG  - 303-5
AB  - This concerns a patient with severe rheumatoid arthritis (RA) and lymphadenopathy 
      (LA) who showed suboptimal clinical response to antitumor necrosis factor alpha 
      (TNFalpha) antibody (Ab), cA2 therapy. The assessment of TNFalpha and IL-6 mRNA 
      expression in the swollen lymph-node (LN) of the patient by reverse 
      transcription, polymerase chain reaction (RT-PCR) before cA2 treatment, showed 
      only enhanced IL-6 production, but not TNFalpha. Moreover, cA2 failed to inhibit 
      in-vitro spontaneous IL-6 production in the LN block culture from the patient. 
      Taken together, these results indicate that IL-6 production in the swollen LNs of 
      the patient might not depend on TNFalpha. This might partly cause suboptimal 
      clinical response to anti-TNFalpha Ab therapy in the patient.
FAU - Saeki, Y
AU  - Saeki Y
AD  - Department of Medicine III, Osaka University Medical School, Suita City, Japan.
FAU - Ohshima, S
AU  - Ohshima S
FAU - Mima, T
AU  - Mima T
FAU - Sasai, M
AU  - Sasai M
FAU - Nishioka, K
AU  - Nishioka K
FAU - Shimizu, M
AU  - Shimizu M
FAU - Suemura, M
AU  - Suemura M
FAU - McCloskey, R
AU  - McCloskey R
FAU - Kishimoto, T
AU  - Kishimoto T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - B72HH48FLU (Infliximab)
SB  - IM
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Arthritis, Rheumatoid/*therapy
MH  - C-Reactive Protein/analysis
MH  - Humans
MH  - Infliximab
MH  - Interleukin-6/metabolism
MH  - Lymph Nodes/metabolism
MH  - Lymphatic Diseases/*therapy
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/*immunology/metabolism
EDAT- 1998/09/29 00:00
MHDA- 1998/09/29 00:01
CRDT- 1998/09/29 00:00
PHST- 1998/09/29 00:00 [pubmed]
PHST- 1998/09/29 00:01 [medline]
PHST- 1998/09/29 00:00 [entrez]
AID - 10.1080/030097498442433 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 1998;27(4):303-5. doi: 10.1080/030097498442433.