PMID- 9752370
OWN - NLM
STAT- MEDLINE
DCOM- 19981019
LR  - 20061115
IS  - 0094-3509 (Print)
IS  - 0094-3509 (Linking)
VI  - 47
IP  - 3
DP  - 1998 Sep
TI  - Should low-molecular-weight heparins replace unfractionated heparin as the agent 
      of choice for adults with deep venous thrombosis?
PG  - 185-92
AB  - BACKGROUND: Several low-molecular-weight heparins (LMWHs) are now approved for 
      use in the United States for the prophylaxis of venous thromboembolism. They are 
      used in Europe for the treatment of deep venous thrombosis (DVT) and pulmonary 
      embolism. This review examines the evidence addressing the question "Should LMWHs 
      replace unfractionated heparin (UFH) in the treatment of adults with DVT?" 
      METHODS: We performed a MEDLINE search using the key words "low-molecular-weight 
      heparin" from the years 1990 to 1998, and the results were assessed using the 
      JAMA Users' Guides to the Medical Literature system. RESULTS: 
      Low-molecular-weight heparins are at least as safe and effective as 
      unfractionated heparin in the treatment of patients with DVT. They are probably 
      more effective and safer. They are more convenient to use and are associated with 
      lower overall costs. CONCLUSIONS: Based on efficacy, safety, convenience, and 
      cost, LMWHs are clearly superior to UFH in the treatment of DVT in primary care. 
      Studies that confirm an expected improvement in patient-oriented outcomes (e.g., 
      mortality and quality of life) need to be done.
FAU - Brewer, D
AU  - Brewer D
AD  - University of Tennessee Medical Center, Knoxville, USA. dbrewer2@UTK.edu
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Fam Pract
JT  - The Journal of family practice
JID - 7502590
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Evidence-Based Medicine
MH  - Health Care Costs
MH  - Heparin/economics/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/economics/*therapeutic use
MH  - Humans
MH  - Recurrence
MH  - Thrombophlebitis/*drug therapy/economics/prevention & control
RF  - 44
EDAT- 1998/09/30 00:00
MHDA- 1998/09/30 00:01
CRDT- 1998/09/30 00:00
PHST- 1998/09/30 00:00 [pubmed]
PHST- 1998/09/30 00:01 [medline]
PHST- 1998/09/30 00:00 [entrez]
PST - ppublish
SO  - J Fam Pract. 1998 Sep;47(3):185-92.