PMID- 9753065
OWN - NLM
STAT- MEDLINE
DCOM- 19981117
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 102
IP  - 5
DP  - 1998 Sep
TI  - Association and clonal distribution of trisomy 12 and 13q14 deletions in chronic 
      lymphocytic leukaemia.
PG  - 1330-4
AB  - The coexistence of trisomy 12 and deletions of chromosome 13 (13q12-q32) has 
      rarely been observed in chronic lymphocytic leukaemia (CLL). Fluorescence in situ 
      hybridization (FISH) performed on 600 consecutive CLL patients revealed the 
      association of trisomy 12 and 13q14 deletion, of at least one of the three 
      markers analysed (RB1, D13S319 and D13S25), in 55 cases (9% of 600 and 46% of 120 
      trisomy 12 cases). Trisomy 12 and isolated RB1 deletion were seen in 14/120 
      cases, trisomy 12 and D13S319/D13S25 deletion with diploid RB1 in 19/118, and 
      trisomy 12 and deletion encompassing the three 13q markers studied in 22/118 
      cases. The heterogenous distribution of trisomy 12 and 13q deletions within the 
      neoplastic B cells suggests that they are secondary rather than primary events in 
      CLL leukaemogenesis.
FAU - Navarro, B
AU  - Navarro B
AD  - Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, 
      London.
FAU - Garcia-Marco, J A
AU  - Garcia-Marco JA
FAU - Jones, D
AU  - Jones D
FAU - Price, C M
AU  - Price CM
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - *Trisomy
EDAT- 1998/09/30 00:00
MHDA- 1998/09/30 00:01
CRDT- 1998/09/30 00:00
PHST- 1998/09/30 00:00 [pubmed]
PHST- 1998/09/30 00:01 [medline]
PHST- 1998/09/30 00:00 [entrez]
AID - 10.1046/j.1365-2141.1998.00891.x [doi]
PST - ppublish
SO  - Br J Haematol. 1998 Sep;102(5):1330-4. doi: 10.1046/j.1365-2141.1998.00891.x.