PMID- 9753210
OWN - NLM
STAT- MEDLINE
DCOM- 19981120
LR  - 20181201
IS  - 0091-2700 (Print)
IS  - 0091-2700 (Linking)
VI  - 38
IP  - 9
DP  - 1998 Sep
TI  - Coadministration of acetaminophen and troglitazone: pharmacokinetics and safety.
PG  - 819-24
AB  - Troglitazone, a PPAR-gamma agonist, enhances the actions of insulin on muscle and 
      liver. It is metabolized predominantly in the liver to a sulfate conjugate and a 
      quinone metabolite. Acetaminophen also undergoes metabolism by conjugation. This 
      three-way crossover study in 12 healthy male volunteers was conducted to 
      investigate the effects of acetaminophen on the metabolism of troglitazone and 
      vice versa. No statistically or clinically relevant differences in area under the 
      concentration-time curve extrapolated to infinity (AUCinfinity) were observed for 
      troglitazone, its quinone metabolite, or acetaminophen. A statistically 
      significant decrease in troglitazone sulfate conjugate during administration with 
      acetaminophen was not clinically relevant. No statistically or clinically 
      relevant differences were observed in maximum concentration (Cmax), time to Cmax 
      (tmax), or elimination half-life of troglitazone, its two main metabolites, and 
      acetaminophen or in acetaminophen urinary sulfate excretion, although there was a 
      slight decrease in acetaminophen glucuronide excretion during administration with 
      troglitazone. Adverse events were minor and similar between treatments. These 
      findings suggest that troglitazone and acetaminophen can be coadministered 
      without adverse clinical consequences.
FAU - Young, M A
AU  - Young MA
AD  - Department of Clinical Pharmacology, Glaxo Wellcome Research and Development Ltd, 
      Middlesex, United Kingdom.
FAU - Lettis, S
AU  - Lettis S
FAU - Eastmond, R
AU  - Eastmond R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - J Clin Pharmacol
JT  - Journal of clinical pharmacology
JID - 0366372
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Chromans)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Thiazoles)
RN  - 0 (Thiazolidinediones)
RN  - 362O9ITL9D (Acetaminophen)
RN  - I66ZZ0ZN0E (Troglitazone)
SB  - IM
MH  - Acetaminophen/adverse effects/*pharmacokinetics/pharmacology
MH  - Administration, Oral
MH  - Adult
MH  - Analgesics, Non-Narcotic/adverse effects/pharmacokinetics/*pharmacology
MH  - Chromans/adverse effects/*pharmacokinetics/pharmacology
MH  - Cross-Over Studies
MH  - Drug Administration Schedule
MH  - Drug Interactions
MH  - Humans
MH  - Hypoglycemic Agents/adverse effects/pharmacokinetics/*pharmacology
MH  - Male
MH  - Thiazoles/adverse effects/*pharmacokinetics/pharmacology
MH  - *Thiazolidinediones
MH  - Troglitazone
EDAT- 1998/09/30 00:00
MHDA- 1998/09/30 00:01
CRDT- 1998/09/30 00:00
PHST- 1998/09/30 00:00 [pubmed]
PHST- 1998/09/30 00:01 [medline]
PHST- 1998/09/30 00:00 [entrez]
PST - ppublish
SO  - J Clin Pharmacol. 1998 Sep;38(9):819-24.