PMID- 9753239
OWN - NLM
STAT- MEDLINE
DCOM- 19981001
LR  - 20061115
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 43
IP  - 9 Suppl
DP  - 1998 Sep
TI  - Increased mRNA levels of transforming growth factor-beta1 and monocyte 
      chemoattractant protein-1 in ulcer relapse caused by interleukin-1beta in rats.
PG  - 134S-138S
AB  - This study investigated the mRNA expression of transforming growth factor-beta1 
      (TGF-beta1) and monocyte chemoattractant protein-1 (MCP-1) in rat gastric tissues 
      in which ulcers had relapsed due to interleukin-1beta (IL-1beta) administration. 
      Rats with healed ulcers were administered IL-1beta (1 microg/kg) and killed after 
      0, 12, 24, or 48 hr. Both TGF-beta1 and MCP-1 mRNA levels were increased in the 
      scarred gastric tissues at 24 hr (fourfold), when ulcers had not relapsed. 
      Furthermore, the expression of these genes also increased in the ulcerated 
      gastric tissues at 48 hr (fivefold), when 90% of healed ulcers had relapsed. On 
      the other hand, the number of macrophages that had infiltrated the scarred 
      gastric tissues at 24 hr was two times higher than that at 0 hr. At 48 hr, the 
      number of macrophages that had infiltrated gastric tissues in which ulcers had 
      relapsed was similar to that at 24 hr. Thus, TGF-beta1 and MCP-1 may be 
      implicated in the macrophage infiltration, thereby leading to ulcer relapse due 
      to IL-1beta.
FAU - Tominaga, K
AU  - Tominaga K
AD  - Third Department of Internal Medicine, Osaka City University Medical School, 
      Osaka, Japan.
FAU - Arakawa, T
AU  - Arakawa T
FAU - Watanabe, T
AU  - Watanabe T
FAU - Tanaka, M
AU  - Tanaka M
FAU - Takaishi, O
AU  - Takaishi O
FAU - Fujiwara, Y
AU  - Fujiwara Y
FAU - Fukuda, T
AU  - Fukuda T
FAU - Higuchi, K
AU  - Higuchi K
FAU - Kim, S
AU  - Kim S
FAU - Yamasaki, K
AU  - Yamasaki K
FAU - Iwao, H
AU  - Iwao H
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Kuroki, T
AU  - Kuroki T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Gastric Mucosa/*metabolism
MH  - Gene Expression Regulation
MH  - Interleukin-1
MH  - Macrophages/metabolism
MH  - Male
MH  - Monocytes/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Recurrence
MH  - Stomach Ulcer/*metabolism
MH  - Time Factors
MH  - Transforming Growth Factor beta/genetics/*metabolism
EDAT- 1998/09/30 00:00
MHDA- 1998/09/30 00:01
CRDT- 1998/09/30 00:00
PHST- 1998/09/30 00:00 [pubmed]
PHST- 1998/09/30 00:01 [medline]
PHST- 1998/09/30 00:00 [entrez]
PST - ppublish
SO  - Dig Dis Sci. 1998 Sep;43(9 Suppl):134S-138S.