PMID- 9754465
OWN - NLM
STAT- MEDLINE
DCOM- 19981203
LR  - 20190831
IS  - 0160-564X (Print)
IS  - 0160-564X (Linking)
VI  - 22
IP  - 9
DP  - 1998 Sep
TI  - Acetate hemodialysis does not increase the frequency of arrhythmia in 
      hemodialysis patients.
PG  - 781-4
AB  - Arrhythmia is one of the most important causes of mortality in patients on 
      hemodialysis and may develop due to cardiovascular diseases or fluid-electrolyte 
      or acid-base abnormalities. Previous studies have shown that acetate hemodialysis 
      (AHD) increased the frequency of arrhythmia. To evaluate the frequency and the 
      causes of arrhythmias during AHD, we studied 33 randomly selected patients (25 
      male and 8 female, mean age of 45+/-18 years) who were under AHD (4 h, 3 
      times/week, mean duration of HD of 38+/-29 months) with the same Cuprophan 
      membranes. All patients underwent a detailed echocardiographic evaluation during 
      the interdialytic period. Twenty-four hours of Holter monitoring was performed 
      starting from the onset of HD. Twelve lead electrocardiography (ECG) was 
      obtained, and venous and arterial blood samples were drawn for serum 
      electrolytes, pH, and arterial blood gas measurements before and after HD. Serum 
      magnesium and potassium levels dropped after AHD (from 2.3+/-0.5 to 1.9+/-0.3 
      mEq/L and from 5+/-0.7 to 3.4 +/-0.4 mEq/L respectively, p < 0.001); on the other 
      hand serum pH, bicarbonate, sodium, and calcium levels were normalized. 
      Electrocardiographic evaluation revealed significant lengthening of the QTc 
      interval (from 433+/-42 to 464+/-43 ms, p < 0.001), which was thought to be 
      related to the decrease in serum magnesium and potassium levels. The frequencies 
      of ventricular premature contractions (VPCs) were not different during AHD and 
      the interdialytic period (8+/-9.1 to 6.5+/-11 contractions/h, p > 0.05). This was 
      also true for supraventricular premature contractions (SVPCs) and 
      supraventricular tachycardia (SVT). Nonsustained ventricular tachycardia was 
      observed in 2 patients during HD and in 1 patient in the interdialytic period. No 
      relation was established between the echocardiographic findings and the frequency 
      of arrhythmia. In our ambulatory electrocardiographic study, the frequencies of 
      VPCs and SVPCs observed during the interdialytic period were only positively 
      correlated with age (r=0.54, p=0.013 and r=0.50, p=0.010, respectively). No 
      relation was found between the frequency of arrhythmia and the gender of the 
      patients; duration of HD; etiology of kidney disease; or serum Na, K, Ca, iCa, 
      Mg, bicarbonate, or pH levels (p > 0.05). In conclusion, the application of AHD 
      does not increase the frequency of arrhythmia in HD patients as had been shown in 
      previous studies.
FAU - Kayatas, M
AU  - Kayatas M
AD  - Department of Nephrology, Baskent University School of Medicine, Ankara, Turkey.
FAU - Erturk, A
AU  - Erturk A
FAU - Muderrisoglu, H
AU  - Muderrisoglu H
FAU - Korkmaz, M E
AU  - Korkmaz ME
FAU - Ozdemir, F N
AU  - Ozdemir FN
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
RN  - 0 (Acetates)
RN  - 0 (Electrolytes)
SB  - IM
MH  - Acetates
MH  - Adult
MH  - Age Factors
MH  - Arrhythmias, Cardiac/epidemiology/*etiology
MH  - Blood Gas Analysis
MH  - Electrocardiography
MH  - Electrolytes/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Renal Dialysis/*adverse effects/methods
MH  - Sex Factors
MH  - Turkey/epidemiology
EDAT- 1998/10/01 00:00
MHDA- 1998/10/01 00:01
CRDT- 1998/10/01 00:00
PHST- 1998/10/01 00:00 [pubmed]
PHST- 1998/10/01 00:01 [medline]
PHST- 1998/10/01 00:00 [entrez]
AID - 10.1046/j.1525-1594.1998.06163.x [doi]
PST - ppublish
SO  - Artif Organs. 1998 Sep;22(9):781-4. doi: 10.1046/j.1525-1594.1998.06163.x.