PMID- 9754676
OWN - NLM
STAT- MEDLINE
DCOM- 19981201
LR  - 20190909
IS  - 0192-0561 (Print)
IS  - 0192-0561 (Linking)
VI  - 20
IP  - 6
DP  - 1998 Jun
TI  - Inhibition of immediate type allergic reactions by the aqueous extract of 
      Kum-Hwang-San.
PG  - 285-94
AB  - We studied the effect of aqueous extract of Kum-Hwang-San (KHS) on mast 
      cell-mediated immediate type allergic reactions. KHS (1-100 microg/site) 
      inhibited concentration-dependently mast cell-dependent ear swelling response 
      induced by compound 48/80 (200 microg/site) in mice by both topical and 
      intradermal application. KHS (0.1-100 microg/site) inhibited 
      concentration-dependently passive cutaneous anaphylaxis induced by 
      anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. 
      KHS also inhibited concentration-dependently the histamine release from the rat 
      peritoneal mast cells (RPMC) by compound 48/80 and anti-DNP IgE. Moreover, KHS 
      had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis 
      factor-alpha (TNF-alpha) secretion from RPMC. These results indicate that KHS 
      inhibits immediate type allergic reactions by inhibition of histamine release and 
      TNF-alpha secretion from mast cells in vivo and in vitro.
FAU - Kim, H
AU  - Kim H
AD  - College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea. 
      hmkim@med.wonkwang.ac.kr
FAU - Shin, H
AU  - Shin H
FAU - Lee, E
AU  - Lee E
FAU - Lee, J
AU  - Lee J
FAU - Jung, J
AU  - Jung J
FAU - An, N
AU  - An N
FAU - Lee, Y
AU  - Lee Y
FAU - Kim, D
AU  - Kim D
FAU - Jippo, T
AU  - Jippo T
FAU - Kitamura, Y
AU  - Kitamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopharmacol
JT  - International journal of immunopharmacology
JID - 7904799
RN  - 0 (Dinitrophenols)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Animals
MH  - Dinitrophenols/immunology
MH  - Drug Hypersensitivity/*drug therapy
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/*drug therapy
MH  - Immunoglobulin E/pharmacology
MH  - Mast Cells/drug effects/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Peritoneal Cavity/cytology
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1998/10/01 00:00
MHDA- 1998/10/01 00:01
CRDT- 1998/10/01 00:00
PHST- 1998/10/01 00:00 [pubmed]
PHST- 1998/10/01 00:01 [medline]
PHST- 1998/10/01 00:00 [entrez]
AID - S0192056198000381 [pii]
AID - 10.1016/s0192-0561(98)00038-1 [doi]
PST - ppublish
SO  - Int J Immunopharmacol. 1998 Jun;20(6):285-94. doi: 10.1016/s0192-0561(98)00038-1.