PMID- 9754859
OWN - NLM
STAT- MEDLINE
DCOM- 19990107
LR  - 20190909
IS  - 0355-3140 (Print)
IS  - 0355-3140 (Linking)
VI  - 24
IP  - 4
DP  - 1998 Aug
TI  - Immunologic and renal markers among photogravure printers exposed to toluene.
PG  - 276-84
AB  - OBJECTIVES: This study assessed immunologic and early renal effects of chronic 
      toluene exposure. METHODS: In a longitudinal study of 92 printers and 74 
      referents, 145 subjects had pre- and poststudy samples of blood and urine taken 
      for the following measurements: immunoglobulin E (IgE), antiglomerular basement 
      membrane (anti-GBM) and antilaminin (anti-LAM) antibodies in blood; creatinine 
      and beta2-microglobulin in blood and urine; and microalbumin, 
      N-acetyl-b-D-glucosaminidase (NAG) and alanine-aminopeptidase in urine. 
      Creatinine clearance was calculated according to the Cockroft-Gault formula. 
      Eight-hour personal air samples were collected twice to assess present exposure 
      to toluene. A job-exposure matrix was developed to estimate past cumulative 
      exposure. Information about potential confounders was recorded by questionnaire. 
      Multiple regression analysis was performed to study dose-effect relations 
      adjusted for age and smoking. RESULTS: No subject was positive for anti-GBM 
      antibodies, and only 12 were positive for anti-LAM. No relation was observed 
      between the markers studied and present exposure to toluene except that 
      creatinine clearance was higher among the exposed subjects than among the 
      referents. A dose-response relation was observed between cumulative toluene 
      exposure and both IgE and NAG excretion. No interaction was observed between 
      hypertension and exposure, but the relationship with NAG did not persist when 
      subjects with hypertension were excluded. Past or present exposure did not alter 
      the 2-year trend of any marker studied. CONCLUSIONS: According to the results of 
      this study, toluene at 50 ppm is not related to detectable renal dysfunction. The 
      increased IgE levels associated with present and past exposure require further 
      investigation.
FAU - Stengel, B
AU  - Stengel B
AD  - INSERM U 170 (National Research Institute on Health and Medicine, Unit 170), 
      Villejuif, France. stengel@vjf.inserm.fr
FAU - Cenee, S
AU  - Cenee S
FAU - Limasset, J C
AU  - Limasset JC
FAU - Diebold, F
AU  - Diebold F
FAU - Michard, D
AU  - Michard D
FAU - Druet, P
AU  - Druet P
FAU - Hemon, D
AU  - Hemon D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Laminin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3FPU23BG52 (Toluene)
SB  - IM
MH  - Adult
MH  - Air Pollutants, Occupational/*adverse effects
MH  - Autoantibodies/*blood
MH  - Biomarkers
MH  - Environmental Monitoring
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Kidney/immunology
MH  - Kidney Failure, Chronic/*chemically induced/diagnosis/immunology
MH  - *Kidney Function Tests
MH  - Laminin/immunology
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/*chemically induced/diagnosis/immunology
MH  - *Printing
MH  - Toluene/*adverse effects
EDAT- 1998/10/01 00:00
MHDA- 1998/10/01 00:01
CRDT- 1998/10/01 00:00
PHST- 1998/10/01 00:00 [pubmed]
PHST- 1998/10/01 00:01 [medline]
PHST- 1998/10/01 00:00 [entrez]
AID - 321 [pii]
AID - 10.5271/sjweh.321 [doi]
PST - ppublish
SO  - Scand J Work Environ Health. 1998 Aug;24(4):276-84. doi: 10.5271/sjweh.321.