PMID- 9754895
OWN - NLM
STAT- MEDLINE
DCOM- 19981203
LR  - 20091119
IS  - 0392-9590 (Print)
IS  - 0392-9590 (Linking)
VI  - 17
IP  - 2
DP  - 1998 Jun
TI  - Restricted usage of T-cell receptor Valpha-Vbeta genes in infiltrating cells in 
      the aortic tissue of a patient with atherosclerotic aortic aneurysm.
PG  - 89-92
AB  - We report a rare case of an atherosclerotic aortic aneurysm with lymphocyte 
      infiltration in which T-cell receptor (TCR) Valpha as well as Vbeta gene usage 
      was restricted. Immunohistochemical studies showed that the infiltrating cells 
      mainly consisted of macrophages, natural killer (NK) cells, cytotoxic T 
      lymphocytes (CTLs) and T-helper (Th) cells, and that there were almost no 
      infiltrating delta T lymphocytes, and human leukocyte antigen (HLA) class I and 
      65-kD heat-shock protein (HSP-65) was not strongly expressed in the aortic 
      tissue. Although the immunohistochemical data were consistent with an ordinary 
      atherosclerotic aortic aneurysm, in which TCR Valpha-Vbeta gene usage is known to 
      be polyclonal, the restricted TCR gene usage suggests that a certain autoimmune 
      mechanism was involved in the pathogenesis of this case similar to Takayasu's 
      arteritis, in which massive infiltration of delta T lymphocytes and strong 
      expression of HSP-65 in the aortic tissue are characteristic.
FAU - Seko, Y
AU  - Seko Y
AD  - Third Department of Internal Medicine, University of Tokyo, Japan.
FAU - Takahashi, N
AU  - Takahashi N
FAU - Sato, O
AU  - Sato O
FAU - Takagi, A
AU  - Takagi A
FAU - Yagita, H
AU  - Yagita H
FAU - Okumura, K
AU  - Okumura K
FAU - Yazaki, Y
AU  - Yazaki Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
RN  - 0 (Bacterial Proteins)
RN  - 0 (Chaperonin 60)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (heat-shock protein 65, Mycobacterium)
RN  - EC 3.6.1.- (Chaperonins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Thoracic/*immunology/pathology
MH  - Arteriosclerosis/*immunology/pathology
MH  - Bacterial Proteins/analysis
MH  - Chaperonin 60
MH  - Chaperonins/analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Macrophages/immunology
MH  - Receptors, Antigen, T-Cell, alpha-beta/*genetics
MH  - T-Lymphocytes/immunology
EDAT- 1998/10/01 00:00
MHDA- 1998/10/01 00:01
CRDT- 1998/10/01 00:00
PHST- 1998/10/01 00:00 [pubmed]
PHST- 1998/10/01 00:01 [medline]
PHST- 1998/10/01 00:00 [entrez]
PST - ppublish
SO  - Int Angiol. 1998 Jun;17(2):89-92.