PMID- 9756245
OWN - NLM
STAT- MEDLINE
DCOM- 19981113
LR  - 20191024
VI  - 22
IP  - 9
DP  - 1998 Sep
TI  - Substrate oxidation and thyroid hormone response to the introduction of a high 
      fat diet in formerly obese women.
PG  - 869-77
AB  - OBJECTIVE: To investigate the adaptation in substrate utilization to a sudden 
      change in dietary composition from a medium fat to a high fat diet, during a 
      three day period in formerly obese and never obese women. METHODS: Energy 
      expenditure (EE) and substrate oxidation rates were measured in eight healthy 
      formerly obese women and eight never obese controls, during four consecutive days 
      in a respiration chamber. The first day and the day prior to the experiment, the 
      subjects consumed a diet with 30 energy-% fat, whereas the diet had 55 energy-% 
      fat on the subsequent three days. RESULTS: The rate of adjustment of oxidative 
      substrate partitioning expressed as 24 h non-protein respiratory quotient (RQnp) 
      was similar in the two groups. RQnp on each of the days was also similar between 
      the two groups, after accounting for a group difference in energy balance, caused 
      by a non-significantly lower EE in the formerly obese women. However, the 
      formerly obese subjects, demonstrated a greater suppression of postprandial fat 
      oxidation after supper, which was unrelated to energy balance. Furthermore, the 
      formerly obese subjects, in contrast to the controls, exhibited a reduction in 
      plasma triiodothyronine/thyroxine ratio (T3/T4) following the high fat diet. A 
      positive correlation between T3/T4 and EE was found in the 16 subjects. 
      CONCLUSIONS: The formerly obese subjects did not show a slower adaptation rate of 
      substrate utilization when challenged with a high fat diet, but exhibited an 
      enhanced suppression of fat oxidation and a lower T3/T4 ratio after supper, when 
      fed a high fat diet.
FAU - Buemann, B
AU  - Buemann B
AD  - Research Department of Human Nutrition, The Royal Veterinary and Agricultural 
      University, Frederiksberg, Denmark.
FAU - Toubro, S
AU  - Toubro S
FAU - Astrup, A
AU  - Astrup A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Dietary Fats)
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Dietary Fats/*administration & dosage/*metabolism
MH  - Energy Intake
MH  - Energy Metabolism
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Kinetics
MH  - Middle Aged
MH  - Obesity/*metabolism
MH  - Oxidation-Reduction
MH  - Oxygen Consumption
MH  - Physical Exertion
MH  - Thyroid Hormones/*blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
EDAT- 1998/10/02 00:00
MHDA- 1998/10/02 00:01
CRDT- 1998/10/02 00:00
PHST- 1998/10/02 00:00 [pubmed]
PHST- 1998/10/02 00:01 [medline]
PHST- 1998/10/02 00:00 [entrez]
AID - 10.1038/sj.ijo.0800674 [doi]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 1998 Sep;22(9):869-77. doi: 
      10.1038/sj.ijo.0800674.