PMID- 9756305
OWN - NLM
STAT- MEDLINE
DCOM- 19981217
LR  - 20190512
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 13
IP  - 8
DP  - 1998 Aug
TI  - Expression of class I human leukocyte antigen (HLA) and beta2-microglobulin is 
      associated with decidualization of human endometrial stromal cells.
PG  - 2246-51
AB  - Human leukocyte antigen (HLA) class I molecules play a central role in the immune 
      system through either presentation of endogenous antigen and activation of T 
      lymphocytes or functional emergence of natural killer (NK) cells. Various types 
      of immune cells are present in the human endometrium and are believed to be 
      involved in reproductive function and/or immunological reaction. However, little 
      is known about the expression status and function of HLA class I molecules in the 
      human endometrium. We therefore examined mRNA expression of HLA class I. In 
      addition, we analysed gene expression and localization of beta2-microglobulin 
      (beta2-MG), which is the non-variant chain of all HLA class I molecules. Compared 
      with non-decidualized tissues, mRNA expression of both HLA class I and beta2-MG 
      was significantly higher in decidualized endometria in the late secretory phase, 
      under progestin treatment and during early pregnancy. Immunohistochemical studies 
      revealed that beta2-MG was localized in decidualized endometrial stromal cells, 
      indicating that the distribution of beta2-MG is topologically correlated with 
      that of CD56bright+ NK cells. In-vitro culture of human endometrial stromal cells 
      demonstrated that HLA class I mRNA was induced during the decidualization by 
      progesterone. Accordingly, the expression of HLA class I molecules is 
      transcriptionally activated along with decidualization of human endometrial 
      stromal cells, and may represent an immuno-endocrine function of the endometrium.
FAU - Komatsu, T
AU  - Komatsu T
AD  - Department of Pathology, Graduate School of Medicine, Kyoto University, Japan.
FAU - Konishi, I
AU  - Konishi I
FAU - Mandai, M
AU  - Mandai M
FAU - Mori, T
AU  - Mori T
FAU - Hiai, H
AU  - Hiai H
FAU - Fukumoto, M
AU  - Fukumoto M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (RNA, Messenger)
RN  - 0 (beta 2-Microglobulin)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Adult
MH  - Cells, Cultured
MH  - Decidua/cytology/*immunology/*metabolism
MH  - Endometrium/cytology/immunology/metabolism
MH  - Female
MH  - Gene Expression/drug effects
MH  - Histocompatibility Antigens Class I/genetics/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Menstrual Cycle/genetics/immunology/metabolism
MH  - Middle Aged
MH  - Pregnancy
MH  - Progesterone/pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Stromal Cells/immunology/metabolism
MH  - beta 2-Microglobulin/genetics/*metabolism
EDAT- 1998/10/02 00:00
MHDA- 1998/10/02 00:01
CRDT- 1998/10/02 00:00
PHST- 1998/10/02 00:00 [pubmed]
PHST- 1998/10/02 00:01 [medline]
PHST- 1998/10/02 00:00 [entrez]
AID - 10.1093/humrep/13.8.2246 [doi]
PST - ppublish
SO  - Hum Reprod. 1998 Aug;13(8):2246-51. doi: 10.1093/humrep/13.8.2246.