PMID- 9757039
OWN - NLM
STAT- MEDLINE
DCOM- 19981116
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 804
IP  - 2
DP  - 1998 Sep 7
TI  - Attenuation of the lordosis-inhibiting effects of 8-OH-DPAT by TFMPP and 
      quipazine.
PG  - 206-11
AB  - Regularly cycling, proestrous female rats received infusions of 200 ng of the 
      serotonin (5-HT) 1A receptor agonist, (+/-) 8-hydroxy 2-(di-n-propylamino) 
      tetralin-HBr (8-OH-DPAT), or 200 ng 8-OH-DPAT and 1000 or 2000 ng of 
      N-(3-trifluoro-methylphenyl) piperazine hydrochloride (TFMPP) or 
      2-(1-piperazinyl) quinoline dimaleate (quipazine). Infusions were made 
      bilaterally into the ventromedial nucleus of the hypothalamus (VMN). Animals 
      receiving 200 ng 8-OH-DPAT exhibited a decline in lordosis behavior following 
      infusion. Rats receiving 8-OH-DPAT and 1000 or 2000 ng quipazine or TFMPP were 
      protected from the lordosis-inhibiting effects of 8-OH-DPAT, alone. Although both 
      quipazine and TFMPP act on multiple 5-HT receptors, they overlap in their agonist 
      action at 5-HT2 receptors. Consequently, these results provide further evidence 
      supporting the contention that within the VMN, both 5-HT1A and 5-HT2 receptor 
      subtypes contribute to the modulation of lordosis behavior in the female rat. The 
      data are discussed in terms of the relative potency of 5-HT at 5-HT receptors 
      mediating inhibition and facilitation of lordosis behavior.
CI  - Copyright 1998 Published by Elsevier Science B.V.
FAU - Wolf, A
AU  - Wolf A
AD  - Department of Biology, Texas Woman's University, Denton, TX 76204, USA.
FAU - Jackson, A
AU  - Jackson A
FAU - Price, T
AU  - Price T
FAU - Trevino, A
AU  - Trevino A
FAU - Caldarola-Pastuszka, M
AU  - Caldarola-Pastuszka M
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - NIGMS 08256/GM/NIGMS NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Piperazines)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 25R3ONU51C (1-(3-trifluoromethylphenyl)piperazine)
RN  - 4WCY05C0SJ (Quipazine)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/*antagonists & inhibitors/*pharmacology
MH  - Animals
MH  - Estrus/physiology
MH  - Female
MH  - Piperazines/*pharmacology
MH  - Posture/physiology
MH  - Quipazine/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin Receptor Agonists/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
EDAT- 1998/10/03 00:00
MHDA- 1998/10/03 00:01
CRDT- 1998/10/03 00:00
PHST- 1998/10/03 00:00 [pubmed]
PHST- 1998/10/03 00:01 [medline]
PHST- 1998/10/03 00:00 [entrez]
AID - S0006-8993(98)00625-8 [pii]
AID - 10.1016/s0006-8993(98)00625-8 [doi]
PST - ppublish
SO  - Brain Res. 1998 Sep 7;804(2):206-11. doi: 10.1016/s0006-8993(98)00625-8.