PMID- 9757042
OWN - NLM
STAT- MEDLINE
DCOM- 19981210
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 807
IP  - 1-2
DP  - 1998 Oct 5
TI  - Effects of various N-terminal fragments of glucagon-like peptide-1(7-36) on food 
      intake in the neonatal chick.
PG  - 214-7
AB  - Recently, the suppressive effect on food intake by the central administration of 
      glucagon-like peptide-1 (GLP-1) has been confirmed in both rats and chicks. The 
      importance of the N-terminal amino acid, histidine, for the bioactivity of 
      GLP-1(7-36) in the central nervous system was suggested, though the role for 
      C-terminal amino acids in the central nervous system has not been reported. The 
      present study was done to elucidate the central effect of N-terminal fragments of 
      GLP-1(7-36) on food intake of the neonatal chick. Intracerebroventricular 
      (i.c.v.) administration of mammalian GLP-1(7-36) inhibited food intake of chicks, 
      but the fragments of GLP-1(7-16) and GLP-1(7-26) did not show the suppressive 
      effect on food intake. Furthermore, the extended fragments, GLP-1(7-30) and 
      GLP-1(7-33), also had no effects on food intake. It is concluded that C-terminal 
      amino acids of GLP-1(7-36) have an important role for the bioactivity in the 
      central nervous system with special reference to feeding behavior.
CI  - Copyright 1998 Elsevier Science B.V.
FAU - Furuse, M
AU  - Furuse M
AD  - Laboratory of Animal Feed Science, Faculty of Agriculture, Kyushu University, 
      Fukuoka 812-8581, Japan. furuse@agr.kyushu-u.ac.jp
FAU - Bungo, T
AU  - Bungo T
FAU - Shimojo, M
AU  - Shimojo M
FAU - Masuda, Y
AU  - Masuda Y
FAU - Saito, N
AU  - Saito N
FAU - Hasegawa, S
AU  - Hasegawa S
FAU - Sugahara, K
AU  - Sugahara K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Peptide Fragments)
RN  - 107444-51-9 (glucagon-like peptide 1 (7-36))
RN  - 62340-29-8 (Glucagon-Like Peptides)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Amino Acid Sequence
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Chickens
MH  - Feeding Behavior/*drug effects
MH  - Glucagon
MH  - Glucagon-Like Peptide 1
MH  - Glucagon-Like Peptides
MH  - Injections, Intraventricular
MH  - Male
MH  - Molecular Sequence Data
MH  - Peptide Fragments/chemistry/*pharmacology
MH  - Sequence Homology, Amino Acid
EDAT- 1998/10/03 00:00
MHDA- 1998/10/03 00:01
CRDT- 1998/10/03 00:00
PHST- 1998/10/03 00:00 [pubmed]
PHST- 1998/10/03 00:01 [medline]
PHST- 1998/10/03 00:00 [entrez]
AID - S0006-8993(98)00798-7 [pii]
AID - 10.1016/s0006-8993(98)00798-7 [doi]
PST - ppublish
SO  - Brain Res. 1998 Oct 5;807(1-2):214-7. doi: 10.1016/s0006-8993(98)00798-7.