PMID- 9761128
OWN - NLM
STAT- MEDLINE
DCOM- 19981015
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 79
IP  - 5
DP  - 1998 Oct 23
TI  - Cytoplasmic accumulation of alpha-catenin is associated with aggressive features 
      in laryngeal squamous-cell carcinoma.
PG  - 546-50
AB  - Aberrations in the function of alpha-catenin (alpha-cat), the anchoring protein 
      of E-cadherin, are believed to cause dysfunction of the cadherin-catenin complex, 
      leading to disturbed cell-cell adhesion. It has been suggested that expression of 
      alpha-cat in human tumours might be a better indicator of aggressive phenotype 
      than expression of E-cadherin. The value of alpha-cat as a prognostic marker in 
      laryngeal squamous cell carcinoma (LSCC) is unclear. To determine the potential 
      prognostic significance of alpha-cat, paraffin-embedded samples from 159 patients 
      with invasive carcinoma left in the section and with long-term follow-up were 
      evaluated immuno-histochemically for alpha-cat expression, and the results were 
      related to histopathological grade, tumour stage and survival. Two patterns of 
      staining were observed: pure membranous staining (57%) and membranous staining 
      with cytoplasmic involvement (43%). Cytoplasmic involvement of alpha-cat was 
      associated with dedifferentiation, advanced tumour stage and nodal status. In 
      addition, supra-glottic tumours showed more often cytoplasmic involvement of 
      alpha-cat than glottic tumours. Patients with cytoplasmic involvement appeared to 
      have a trend towards poor overall survival, though without statistical 
      significance. These results suggest that cytoplasmic involvement of alpha-cat is 
      associated with aggressive behaviour and metastatic phenotype of LSCC.
FAU - Hirvikoski, P
AU  - Hirvikoski P
AD  - Department of Oncology, Kuopio University Hospital, Finland. 
      pasi.hirvikoski@uku.fi
FAU - Kumpulainen, E J
AU  - Kumpulainen EJ
FAU - Virtaniemi, J A
AU  - Virtaniemi JA
FAU - Helin, H J
AU  - Helin HJ
FAU - Rantala, I
AU  - Rantala I
FAU - Johansson, R T
AU  - Johansson RT
FAU - Juhola, M
AU  - Juhola M
FAU - Kosma, V M
AU  - Kosma VM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (CTNNA1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (alpha Catenin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cadherins/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Cytoplasm/*metabolism
MH  - Cytoskeletal Proteins/analysis/*metabolism
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Tissue Embedding
MH  - alpha Catenin
EDAT- 1998/10/07 04:47
MHDA- 2000/06/20 09:00
CRDT- 1998/10/07 04:47
PHST- 1998/10/07 04:47 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/10/07 04:47 [entrez]
AID - 10.1002/(SICI)1097-0215(19981023)79:5<546::AID-IJC18>3.0.CO;2-# [pii]
AID - 10.1002/(sici)1097-0215(19981023)79:5<546::aid-ijc18>3.0.co;2-# [doi]
PST - ppublish
SO  - Int J Cancer. 1998 Oct 23;79(5):546-50. doi: 
      10.1002/(sici)1097-0215(19981023)79:5<546::aid-ijc18>3.0.co;2-#.