PMID- 9763899
OWN - NLM
STAT- MEDLINE
DCOM- 19981020
LR  - 20041117
IS  - 0041-4301 (Print)
IS  - 0041-4301 (Linking)
VI  - 40
IP  - 3
DP  - 1998 Jul-Sep
TI  - Pro-inflammatory cytokines, lymphocyte subsets and intravenous immunoglobulin 
      therapy in Guillain-Barre syndrome.
PG  - 357-63
AB  - Both cell-mediated immunity and humoral factors are involved in the pathogenesis 
      of Guillain-Barre syndrome (GBS). Intravenous immunoglobulin (IVIG) has been 
      reported to be a practical, effective and safe treatment in childhood GBS, 
      although the mode of action of IVIG remains uncertain. We studied 
      pro-inflammatory cytokines (interleukin-2, interleukin-1 alpha and tumor necrosis 
      factor-alpha) in plasma and cerebrospinal fluid (CSF) and lymphocyte subsets in 
      peripheral blood both in the acute phase and in the recovery period in six 
      children with GBS treated with IVIG. Flow cytometry was used to determine the 
      subsets of lymphocytes in peripheral blood, and cytokines analyses were performed 
      by using ELISA technique. Results were compared with a control group of 20 
      healthy children. A standard protocol of IVIG (400 mg/kg/day for 5 days) was 
      administered to all the patients. Plasma interleukin-2 concentrations and the 
      number of HLA DR+ active T cells in peripheral blood were significantly higher in 
      the acute phase of the disease than in the recovery period and in healthy 
      controls. There was no significant difference in the other cytokine 
      concentrations in plasma and CSF or in the other lymphocyte subsets in peripheral 
      blood. Our data indicate that IVIG may provide its possible therapeutic effect by 
      acting in the cell-mediated immunity in GBS patients.
FAU - Tekgul, H
AU  - Tekgul H
AD  - Department of Pediatrics, Ege University, Faculty of Medicine, Izmir.
FAU - Kutukculer, N
AU  - Kutukculer N
FAU - Caglayan, S
AU  - Caglayan S
FAU - Tutuncuoglu, S
AU  - Tutuncuoglu S
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk J Pediatr
JT  - The Turkish journal of pediatrics
JID - 0417505
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/blood/cerebrospinal fluid/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - *Lymphocyte Subsets
MH  - Male
MH  - Polyradiculoneuropathy/*metabolism/*therapy
EDAT- 1998/10/09 00:00
MHDA- 1998/10/09 00:01
CRDT- 1998/10/09 00:00
PHST- 1998/10/09 00:00 [pubmed]
PHST- 1998/10/09 00:01 [medline]
PHST- 1998/10/09 00:00 [entrez]
PST - ppublish
SO  - Turk J Pediatr. 1998 Jul-Sep;40(3):357-63.