PMID- 9764358
OWN - NLM
STAT- MEDLINE
DCOM- 19981202
LR  - 20211203
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 40
IP  - 3
DP  - 1998 Sep
TI  - HLA-G polymorphisms: ethnic differences and implications for potential molecule 
      function.
PG  - 145-57
AB  - PROBLEM: Human leukocyte antigen (HLA)-G is uniquely expressed on extravillous 
      cytotrophoblasts of the placenta and is postulated to be a mediator of maternal 
      immune tolerance. Although it was originally considered to be nonpolymorphic, 
      variations of the HLA-G DNA sequence have been reported, and a limited number of 
      HLA-G alleles been defined. METHOD OF STUDY: The HLA-G wild-type sequence was 
      compared with HLA-A2 with regard to the conservation of functionally essential 
      parts of classical HLA-I molecules. HLA-G polymorphisms were analyzed under the 
      aspect of ethnic differences, site, and consequences for postulated molecule 
      functions. RESULTS: HLA-G exhibits a high degree of conservation relative to 
      HLA-A2 in functionally relevant sites of HLA-class I molecules. However, 
      polymorphic sites in HLA-G and classical HLA loci are not congruent. CONCLUSION: 
      The type and localization of HLA-G polymorphisms suggest that different parts of 
      HLA-G molecule underlie different selective constraints.
FAU - van der Ven, K
AU  - van der Ven K
AD  - University of Bonn, Department of Obstetrics and Gynecology, Germany.
FAU - Skrablin, S
AU  - Skrablin S
FAU - Ober, C
AU  - Ober C
FAU - Krebs, D
AU  - Krebs D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Ethnicity/*genetics
MH  - Female
MH  - HLA Antigens/*genetics/physiology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics/physiology
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Pregnancy
RF  - 54
EDAT- 1998/10/09 00:00
MHDA- 1998/10/09 00:01
CRDT- 1998/10/09 00:00
PHST- 1998/10/09 00:00 [pubmed]
PHST- 1998/10/09 00:01 [medline]
PHST- 1998/10/09 00:00 [entrez]
AID - 10.1111/j.1600-0897.1998.tb00406.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 1998 Sep;40(3):145-57. doi: 
      10.1111/j.1600-0897.1998.tb00406.x.