PMID- 9764379
OWN - NLM
STAT- MEDLINE
DCOM- 19981118
LR  - 20190915
IS  - 0936-6555 (Print)
IS  - 0936-6555 (Linking)
VI  - 10
IP  - 4
DP  - 1998
TI  - The importance of cytogenetics and associated molecular techniques in the 
      management of patients with leukaemia.
PG  - 255-61
AB  - The cytogenetic analysis of haematological malignancies plays a major role in 
      diagnosis. A large number of non-random chromosomal abnormalities are associated 
      with specific types of leukaemia. Often, the cytogenetic result provides the 
      definitive diagnosis. The recent developments in molecular cytogenetic 
      technologies, in association with conventional cytogenetic analysis, have 
      improved the accuracy of the results and led to the finding of new chromosomal 
      abnormalities in leukaemia. Patients may be monitored by cytogenetics, molecular 
      techniques and/or fluorescence in situ hybridization (FISH) during the course of 
      their management, for evidence of minimal residual disease. These techniques also 
      provide a useful method for monitoring patients following bone marrow 
      transplantation, particularly when the patient and the donor are of the opposite 
      sex. The cytogenetic result is an independent prognostic indicator, with certain 
      karyotypes associated with a good prognosis, although others indicate a poor 
      outcome.
FAU - Harrison, C J
AU  - Harrison CJ
AD  - Cytogenetics Laboratory, Department of Haematology, Royal Free Hospital School of 
      Medicine, London, UK.
FAU - Secker-Walker, L M
AU  - Secker-Walker LM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Oncol (R Coll Radiol)
JT  - Clinical oncology (Royal College of Radiologists (Great Britain))
JID - 9002902
SB  - IM
MH  - Bone Marrow Transplantation
MH  - *Chromosome Aberrations
MH  - *Chromosome Mapping
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia/*genetics/pathology/therapy
MH  - Male
MH  - Prognosis
MH  - Remission Induction
RF  - 54
EDAT- 1998/10/09 00:00
MHDA- 1998/10/09 00:01
CRDT- 1998/10/09 00:00
PHST- 1998/10/09 00:00 [pubmed]
PHST- 1998/10/09 00:01 [medline]
PHST- 1998/10/09 00:00 [entrez]
AID - S0936-6555(98)80013-7 [pii]
AID - 10.1016/s0936-6555(98)80013-7 [doi]
PST - ppublish
SO  - Clin Oncol (R Coll Radiol). 1998;10(4):255-61. doi: 
      10.1016/s0936-6555(98)80013-7.