PMID- 9766405
OWN - NLM
STAT- MEDLINE
DCOM- 19981217
LR  - 20190905
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 400
IP  - 2
DP  - 1998 Oct 19
TI  - Neurogenesis and migration of receptor neurons in the vomeronasal sensory 
      epithelium in the opossum, Monodelphis domestica.
PG  - 287-97
AB  - The sensory epithelium of the vomeronasal organ (VNO) contains primary 
      chemosensory receptor neurons that project to the accessory olfactory bulb (AOB). 
      In the present study, neurogenesis and cell migration in the sensory epithelium 
      of the VNO were analyzed in opossums (Monodelphis domestica) by using 
      bromodeoxyuridine (BrdU) labeling. 1) In the VNO of normal adult opossums, BrdU 
      labeled a small number of cells localized in the basal region of the sensory 
      epithelium. After 1 or 2 weeks of survival, the labeled cells appeared in the 
      receptor cell layers and became receptor neurons, as indicated by coexpression of 
      the G proteins G(i alpha2) or G(o alpha). 2) In the VNO in which the receptor 
      neurons had been destroyed by removing the AOB, the number of BrdU-labeled cells 
      in the reconstituting sensory epithelium was greatly increased compared with that 
      in the intact VNO. The labeled cells were also located in the basal region of the 
      sensory epithelium. 3) In the developing VNO (at postnatal day 10), more cells in 
      the basal region of the sensory epithelium were labeled than in the adult VNO, 
      indicating rapid cell proliferation; and there appeared to be more labeled cells 
      in the basal region near the margins of the sensory epithelium where it meets the 
      nonsensory epithelium. These observations demonstrate that, in the opossum VNO, 
      there is a population of proliferating cells in the basal region close to the 
      basal lamina in the sensory epithelium. The newly generated neurons in the basal 
      region migrate vertically into the receptor cell layer.
FAU - Jia, C
AU  - Jia C
AD  - Program in Neural and Behavioral Sciences, State University of New York Health 
      Science Center at Brooklyn, 11203, USA.
FAU - Halpern, M
AU  - Halpern M
LA  - eng
GR  - DC02745/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Bromodeoxyuridine
MH  - Cell Movement/physiology
MH  - Epithelial Cells/physiology
MH  - Immunohistochemistry
MH  - Olfactory Pathways/*physiology
MH  - Olfactory Receptor Neurons/*physiology
MH  - Opossums/*physiology
MH  - Vomeronasal Organ/cytology/*growth & development
EDAT- 1998/10/10 02:12
MHDA- 2000/06/20 09:00
CRDT- 1998/10/10 02:12
PHST- 1998/10/10 02:12 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/10/10 02:12 [entrez]
AID - 10.1002/(SICI)1096-9861(19981019)400:2<287::AID-CNE9>3.0.CO;2-5 [pii]
AID - 10.1002/(sici)1096-9861(19981019)400:2<287::aid-cne9>3.0.co;2-5 [doi]
PST - ppublish
SO  - J Comp Neurol. 1998 Oct 19;400(2):287-97. doi: 
      10.1002/(sici)1096-9861(19981019)400:2<287::aid-cne9>3.0.co;2-5.