PMID- 9766714 OWN - NLM STAT- MEDLINE DCOM- 19981230 LR - 20220409 IS - 0047-1828 (Print) IS - 0047-1828 (Linking) VI - 62 IP - 9 DP - 1998 Sep TI - Simultaneous elevation of the levels of circulating monocyte chemoattractant protein-1 and tissue factor in acute coronary syndromes. PG - 710-2 AB - The levels of circulating monocyte chemoattractant protein-1 (MCP-1) and tissue factor (TF) were examined on admission in 46 consecutive patients with acute coronary syndromes (ACS) and 30 patients with stable exertional angina (SEA). The plasma levels of both MCP-1 and TF were higher in the ACS patients than in the SEA patients (MCP-1: p<0.001; TF: p<0.001). Only the circulating TF level related to the number of diseased vessels. A positive correlation between plasma MCP-1 and TF levels was found (r=0.476, p<0.001). These results suggest that circulating MCP-1 plays an important role in the pathogenesis and/or development of ACS. FAU - Nishiyama, K AU - Nishiyama K AD - Division of Cardiology, Kumamoto University School of Medicine, Kumamoto City, Japan. FAU - Ogawa, H AU - Ogawa H FAU - Yasue, H AU - Yasue H FAU - Soejima, H AU - Soejima H FAU - Misumi, K AU - Misumi K FAU - Takazoe, K AU - Takazoe K FAU - Yoshimura, M AU - Yoshimura M FAU - Kugiyama, K AU - Kugiyama K FAU - Tsuji, I AU - Tsuji I FAU - Kumeda, K AU - Kumeda K LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Japan TA - Jpn Circ J JT - Japanese circulation journal JID - 7806868 RN - 0 (Chemokine CCL2) RN - 9035-58-9 (Thromboplastin) SB - IM MH - Acute Disease MH - Aged MH - Angina Pectoris/blood/etiology MH - Angina, Unstable/*blood/etiology MH - Chemokine CCL2/*blood MH - Female MH - Humans MH - Inflammation MH - Male MH - Middle Aged MH - Monocytes/*physiology MH - Myocardial Infarction/*blood/etiology MH - Thromboplastin/*analysis EDAT- 1998/10/10 00:00 MHDA- 1998/10/10 00:01 CRDT- 1998/10/10 00:00 PHST- 1998/10/10 00:00 [pubmed] PHST- 1998/10/10 00:01 [medline] PHST- 1998/10/10 00:00 [entrez] AID - 10.1253/jcj.62.710 [doi] PST - ppublish SO - Jpn Circ J. 1998 Sep;62(9):710-2. doi: 10.1253/jcj.62.710.