PMID- 9767463
OWN - NLM
STAT- MEDLINE
DCOM- 19990128
LR  - 20190512
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 95
IP  - 1
DP  - 1998 Sep
TI  - Eosinophilia, IgE production, and cytokine production by lung T cells in surface 
      CD4-deficient mutant mice infected with Toxocara canis.
PG  - 97-104
AB  - Mutant mice deficient in CD4+ T cells and their normal and heterozygous 
      littermates were infected with Toxocara canis, and compared for eosinophilia, 
      total and Toxocara-specific immunoglobulin E (IgE) production, and in vitro 
      cytokine production by lung cells. The numbers of eosinophils in the peripheral 
      blood of normal and heterozygous mice peaked on days 10 and 21, although mutant 
      mice showed eosinophilia with a peak on day 10. This indicates that the first 
      peak on day 10 is CD4 independent and the second peak is CD4 dependent. Before 
      infection, the levels of total IgE had no significant difference among the three 
      groups of mice. Total and Toxocara-specific IgE in all genotypes of mice 
      increased after infection, and was the highest in normal mice and the lowest in 
      mutant mice. In vitro production of interleukin (IL)-5 and IL-4 by total lung 
      cells was the highest in normal mice and the lowest in mutant mice. CD4+ and CD4- 
      CD8- T lymphocytes, but not CD8+ T lymphocytes produced IL-5 and IL-4 when 
      incubated with anti-CD3 monoclonal antibody (mAb) and lung-adherent cells. These 
      results indicated that IL-5 and IL-4 were produced mainly by CD4+ cells and 
      partly by CD4- CD8- cells, but not by CD8+ cells. In addition, cytokine 
      production by CD4+ cells was affected by the number of CD4 molecules on their 
      surface.
FAU - Takamoto, M
AU  - Takamoto M
AD  - Department of Parasitology, Shinshu University School of Medicine, Matsumoto City 
      390, Japan.
FAU - Wang, Z X
AU  - Wang ZX
FAU - Watanabe, N
AU  - Watanabe N
FAU - Matsuzawa, A
AU  - Matsuzawa A
FAU - Nariuchi, H
AU  - Nariuchi H
FAU - Sugane, K
AU  - Sugane K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-5)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/pharmacology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cells, Cultured
MH  - Cytokines/*blood
MH  - Flow Cytometry
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/blood
MH  - Interleukin-4/biosynthesis
MH  - Interleukin-5/biosynthesis
MH  - Lung/immunology/*parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Mutant Strains
MH  - Pulmonary Eosinophilia/immunology/*parasitology
MH  - T-Lymphocytes/immunology
MH  - *Toxocara canis
MH  - Toxocariasis/*immunology
PMC - PMC1364382
EDAT- 1998/10/10 00:00
MHDA- 1998/10/10 00:01
PMCR- 1999/09/01
CRDT- 1998/10/10 00:00
PHST- 1998/10/10 00:00 [pubmed]
PHST- 1998/10/10 00:01 [medline]
PHST- 1998/10/10 00:00 [entrez]
PHST- 1999/09/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2567.1998.00575.x [doi]
PST - ppublish
SO  - Immunology. 1998 Sep;95(1):97-104. doi: 10.1046/j.1365-2567.1998.00575.x.