PMID- 9768716
OWN - NLM
STAT- MEDLINE
DCOM- 19981020
LR  - 20201216
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 32
IP  - 4
DP  - 1998 Oct
TI  - Right ventricular ejection fraction is an independent predictor of survival in 
      patients with moderate heart failure.
PG  - 948-54
AB  - OBJECTIVES: We sought to study the relationship between survival and right 
      ventricular ejection fraction (RVEF) in a subgroup of patients with moderate 
      congestive heart failure (CHF). BACKGROUND: It has been demonstrated that RVEF is 
      an independent predictor of survival in patients with advanced CHF. METHODS: 
      Cardiopulmonary exercise testing and radionuclide angiography (to determine right 
      and left ventricular ejection fraction) were prospectively performed in 205 
      consecutive patients with moderate CHF (140 patients in New York Heart 
      Association [NYHA] class II, 65 in class III). RESULTS: Left ventricular ejection 
      fraction was 29.3%+/-10.1%, RVEF was 37.5%+/-14.6% and peak oxygen consumption 
      (VO2) was 16.2+/-5.4 ml/min/kg (60.2%+/-19% of maximal predicted VO2). After a 
      median follow-up period of 755 days, there were 44 cardiac-related deaths, 3 
      deaths from noncardiac causes and 15 transplantations of whom 2 were urgent; 1 
      patient was lost to follow-up. Multivariate analysis showed that three 
      variables-NYHA classification, percent of maximal predicted VO2 and RVEF-were 
      independent predictors of both survival and event-free cardiac survival. Left 
      ventricular ejection fraction and peak VO2 normalized to body weight had no 
      predictive value. The event-free survival rates from cardiovascular mortality and 
      urgent transplantation at 1 year were 80%, 90% and 95% in patients with an RVEF 
      <25%, with a RVEF > or =25% and <35% and with a RVEF > or =35%, respectively. At 
      2 years, survival rates were 59%, 77% and 93% in the same subgroups, 
      respectively. CONCLUSIONS: In addition to the NYHA classification and to the 
      percent of maximal predicted VO2, RVEF is an independent predictor of survival in 
      patients with moderate CHF.
FAU - de Groote, P
AU  - de Groote P
AD  - Service de Cardiologie C, Hopital Cardiologique, Lille, France. 
      pdegroote@chru-lille.fr
FAU - Millaire, A
AU  - Millaire A
FAU - Foucher-Hossein, C
AU  - Foucher-Hossein C
FAU - Nugue, O
AU  - Nugue O
FAU - Marchandise, X
AU  - Marchandise X
FAU - Ducloux, G
AU  - Ducloux G
FAU - Lablanche, J M
AU  - Lablanche JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Disease-Free Survival
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/diagnostic imaging/*mortality/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Oxygen Consumption
MH  - Prospective Studies
MH  - ROC Curve
MH  - Radionuclide Angiography
MH  - Risk Factors
MH  - *Stroke Volume
MH  - Survival Rate
MH  - Ventricular Function, Left
MH  - *Ventricular Function, Right
EDAT- 1998/10/13 00:00
MHDA- 1998/10/13 00:01
CRDT- 1998/10/13 00:00
PHST- 1998/10/13 00:00 [pubmed]
PHST- 1998/10/13 00:01 [medline]
PHST- 1998/10/13 00:00 [entrez]
AID - S0735-1097(98)00337-4 [pii]
AID - 10.1016/s0735-1097(98)00337-4 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 1998 Oct;32(4):948-54. doi: 10.1016/s0735-1097(98)00337-4.