PMID- 9769473
OWN - NLM
STAT- MEDLINE
DCOM- 19981201
LR  - 20180213
IS  - 1015-2008 (Print)
IS  - 1015-2008 (Linking)
VI  - 66
IP  - 6
DP  - 1998
TI  - Detection of alterations in chromosomes 16 and 1 by fluorescence in situ 
      hybridization in breast tumors cytologically or histologically equivocal for 
      malignancy.
PG  - 268-73
AB  - Structural and numerical alterations, and fusion of chromosomes 16 and 1 have 
      been shown to occur frequently in low-grade breast carcinoma, but not in benign 
      papilloma by fluorescence in situ hybridization (FISH). We carried out FISH 
      analysis of 11 benign tumors and 3 breast tumors for which the preoperative 
      diagnosis was equivocal for cancer. In 11 benign lesions and 1 benign phyllode 
      tumor which was cytologically equivocal for malignancy, alteration of the 
      chromosome 16 or 1 signal was not detected as a predominant cell clone. On the 
      other hand, in 1 grade 1 invasive ductal carcinoma which was judged as equivocal 
      for malignancy and 1 marked adenosis with atypia which was judged as malignant by 
      fine-needle aspiration cytology, the majority of constituent tumor cells showed 
      fusion of chromosomes 16 and 1. Detection of alterations in chromosomes 16 and 1 
      as a predominant clone was suggested to be an indicator of lesion malignancy even 
      though the grade of malignancy may not be high. As a supportive diagnostic 
      procedure, FISH analysis may give information about the nature of lesions, when 
      the lesions are clinically or pathologically equivocal for cancer.
FAU - Tsuda, H
AU  - Tsuda H
AD  - Pathology Division, National Cancer Center Research Institute and Hospital, 
      Tokyo, Japan. hstsuda@gan2.ncc.go.jp
FAU - Takarabe, T
AU  - Takarabe T
FAU - Shimamura, K
AU  - Shimamura K
FAU - Hirohashi, S
AU  - Hirohashi S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
SB  - IM
MH  - Biopsy, Needle
MH  - Breast Neoplasms/diagnosis/*genetics/*pathology
MH  - Carcinoma, Ductal, Breast/diagnosis/genetics/pathology
MH  - Case-Control Studies
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Phyllodes Tumor/diagnosis/genetics/pathology
EDAT- 1998/10/14 02:02
MHDA- 2000/08/16 11:00
CRDT- 1998/10/14 02:02
PHST- 1998/10/14 02:02 [pubmed]
PHST- 2000/08/16 11:00 [medline]
PHST- 1998/10/14 02:02 [entrez]
AID - pat66268 [pii]
AID - 10.1159/000028033 [doi]
PST - ppublish
SO  - Pathobiology. 1998;66(6):268-73. doi: 10.1159/000028033.