PMID- 9772497
OWN - NLM
STAT- MEDLINE
DCOM- 19981104
LR  - 20061115
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 77
IP  - 5
DP  - 1997 May
TI  - [The relationship between autoimmune thyroiditis and TNF alpha: a preliminary 
      study].
PG  - 378-81
AB  - OBJECTIVE: To observe the action of tumor necrosis factor-alpha (TNF alpha) in 
      the pathogenesis of autoimmune thyroiditis. METHODS: The activity of TNF alpha of 
      peripheral blood mononuclear cells was detected in 25 cases of autoimmune 
      thyroiditis, 9 cases of Grave's disease, and 18 normal controls by ELISA and 
      bioassay. RESULTS: The activity of TNF alpha in patients with autoimmune 
      thyrioditis was significantly higher than that in normal controls (P < 0.001), 
      and in patients with Grave's diseases significantly lower than that in normal 
      controls (P < 0.01). TNF alpha activity detected by two methods showed a good 
      correlation (r = 0.972 P < 0.001). There were a negative correlation between TNF 
      alpha and TT3 or FT3 (r = -0.437, -0.432 respectively, both P < 0.05) and a 
      positive correlation between TNF alpha and TPO-Ab or TGA (r = 0.53, 0.51 
      respectively, both P < 0.01). TNF alpha activity was not associated with the 
      period of disease and the size of thyriod. CONCLUSION: TNF alpha exerts an 
      important role in the pathogenesis of autoimmune thyroiditis.
FAU - Zhang, J
AU  - Zhang J
AD  - Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 
      Beijing.
FAU - Bai, Y
AU  - Bai Y
FAU - Yu, M
AU  - Yu M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Autoantibodies)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Adult
MH  - Autoantibodies/blood
MH  - Female
MH  - Graves Disease/blood
MH  - Humans
MH  - Iodide Peroxidase/immunology
MH  - Male
MH  - Middle Aged
MH  - Thyroiditis, Autoimmune/*blood/etiology
MH  - Tumor Necrosis Factor-alpha/*metabolism/physiology
EDAT- 1997/05/01 00:00
MHDA- 1998/10/17 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1998/10/17 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 1997 May;77(5):378-81.