PMID- 9772522
OWN - NLM
STAT- MEDLINE
DCOM- 19990427
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 77
IP  - 10
DP  - 1997 Oct
TI  - [Clinical efficacy of prolonged therapy with NO on patients with pulmonary 
      hypertension].
PG  - 762-4
AB  - OBJECTIVE: To determine the safety and clinical efficacy of prolonged NO 
      administration in patients with pulmonary hypertension. METHOD: Clinical efficacy 
      of prolonged treatment (28 days) with NO (20 ppm) in 17 patients with pulmonary 
      hypertension was observed by chest X-ray film, ECG, Doppler echocardiography, 
      analysis of arterial blood gases and the other laboratory investigations. 
      RESULTS: After prolonged treatment with NO, regurgitation velocity and peak 
      pressure gradient across tricuspid valves during systole reduced by 11.8% and 
      22.6%, respectively (P < 0.0001). Ejection fraction of right ventricle, stroke 
      volume and cardiac output of left ventricle, partial oxygen pressure and oxygen 
      saturation of arterial blood increased by 29.9%, 60.3%, 37.8%, 21.7% and 3.8% 
      (all statistics; P < 0.0001), respectively. The class of heart function by New 
      York Heart Association (NYHA) was improved dramatically (P < 0.01). Heart rate 
      also reduced from 96 +/- 12 bpm to 83 +/- 10 bpm (P < 0.0001). But systemic 
      artery pressure and the concentration of blood methemoglobin which reflected NO 
      toxicity did not change obviously (P > 0.05). CONCLUSION: Clinical efficacy of 
      prolonged treatment with NO is satisfied in patients with pulmonary hypertension. 
      Significant clinical side effects and toxicities are not seen during prolonged 
      treatment with NO.
FAU - He, J G
AU  - He JG
AD  - Fuwai Heart Hospital and Institute of Cardiovascular Diseases, Chinese Academy of 
      Medical Sciences, Beijing.
FAU - Cheng, X
AU  - Cheng X
FAU - Xiong, C
AU  - Xiong C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Administration, Inhalation
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*administration & dosage/adverse effects
MH  - Time Factors
EDAT- 1998/10/17 00:00
MHDA- 1998/10/17 00:01
CRDT- 1998/10/17 00:00
PHST- 1998/10/17 00:00 [pubmed]
PHST- 1998/10/17 00:01 [medline]
PHST- 1998/10/17 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 1997 Oct;77(10):762-4.