PMID- 9773936
OWN - NLM
STAT- MEDLINE
DCOM- 19981215
LR  - 20190921
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 33
IP  - 5
DP  - 1998 Oct
TI  - Primary gastric Burkitt's lymphoma presenting with c-myc gene rearrangement.
PG  - 710-5
AB  - A 54-year-old man with primary gastric Burkitt's lymphoma is described. He was 
      evaluated for appetite loss and intermittent midepigastric pain. Upper 
      gastroduodenal endoscopy detected an ulcer in the lesser curvature of the body, 
      and biopsy specimens revealed infiltration of medium-sized lymphoblasts with 
      "starry sky" macrophages. The infiltrated cells were positive for a B-cell 
      marker. Abdominal computed tomography scan demonstrated marked enlargement of the 
      gastric wall, but no enlargement of lymph nodes. These findings led us to 
      diagnose primary gastric Burkitt's lymphoma. The patient responded dramatically 
      to CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) 
      chemotherapy, but 6 months after his initial admission, the disease recurred in 
      the stomach and bone marrow. Lymphoblastic cells were positive for B-cell markers 
      (CD 10, 19, 20, and human leukocyte antigen [HLA]-DR) and showed an abnormal 
      karyotype, 47, XY, t(8;14)(q24;q32), +12. In these cells, the Epstein-Barr virus 
      genome was detected by polymerase chain reaction. Southern blot analysis revealed 
      rearrangement of Ig heavy and light chain genes. In addition, c-myc gene 
      rearrangement was detected. Eight months after the beginning of chemotherapy, the 
      patient died of central nervous system involvement. To our knowledge, this is the 
      first description of a genetic analysis of primary gastric Burkitt's lymphoma.
FAU - Andoh, A
AU  - Andoh A
AD  - Department of Internal Medicine, Shiga University of Medical Science, Seta 
      Tukinowa, Otsu, Japan.
FAU - Takaya, H
AU  - Takaya H
FAU - Bamba, M
AU  - Bamba M
FAU - Sakumoto, H
AU  - Sakumoto H
FAU - Inoue, T
AU  - Inoue T
FAU - Tujikawa, T
AU  - Tujikawa T
FAU - Koyama, S
AU  - Koyama S
FAU - Fujiyama, Y
AU  - Fujiyama Y
FAU - Bamba, T
AU  - Bamba T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
SB  - IM
CIN - J Gastroenterol. 1998 Oct;33(5):782-3. PMID: 9773953
MH  - Blotting, Southern
MH  - Burkitt Lymphoma/*diagnosis/*genetics/pathology
MH  - Diagnosis, Differential
MH  - Fatal Outcome
MH  - Genes, myc/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Stomach Neoplasms/*diagnosis/*genetics/pathology
EDAT- 1998/10/17 00:00
MHDA- 1998/10/17 00:01
CRDT- 1998/10/17 00:00
PHST- 1998/10/17 00:00 [pubmed]
PHST- 1998/10/17 00:01 [medline]
PHST- 1998/10/17 00:00 [entrez]
AID - 10.1007/s005350050159 [doi]
PST - ppublish
SO  - J Gastroenterol. 1998 Oct;33(5):710-5. doi: 10.1007/s005350050159.