PMID- 9773945
OWN - NLM
STAT- MEDLINE
DCOM- 19981215
LR  - 20190921
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 33
IP  - 5
DP  - 1998 Oct
TI  - Activated hepatic stellate cells participate in liver fibrosis in a patient with 
      transfusional iron overload.
PG  - 751-4
AB  - We describe liver fibrosis caused by iron overload after a long history of blood 
      transfusion in a patient with chronic renal failure. Pertinent laboratory data 
      were: serum (s)-Fe 148 microg/dl; unsaturated iron binding capacity (UIBC) 14 
      microg/dl; s-ferritin 9350 ng/ml; human leukocyte antigen (HLA) A2, A24, B39, 
      B55, Cw1, Cw7. Computed tomography revealed a high density in the liver, and 
      laparoscopy revealed a brown liver. Liver histology showed bridging fibrosis from 
      portal tracts. A heavy iron deposit was seen in Kupffer cells as well as in 
      hepatocytes surrounded by fibrosis around the portal tracts. Immunocytochemistry 
      revealed alpha-smooth muscle actin in many stellate cells distributed along the 
      fibrotic area, and electron microscopy revealed infiltrating myofibroblastic 
      stellate cells coexisting with collagen fibers around degenerated hepatocytes 
      containing iron deposits. The findings are consistent with the notion that 
      stellate cells play an important role in liver fibrogenesis in both genetic and 
      transfusional iron overload hemochromatosis.
FAU - Harada, Y
AU  - Harada Y
AD  - Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, 
      Japan.
FAU - Iwai, M
AU  - Iwai M
FAU - Kakusui, M
AU  - Kakusui M
FAU - Mori, T
AU  - Mori T
FAU - Tada, K
AU  - Tada K
FAU - Ishii, Y
AU  - Ishii Y
FAU - Okanoue, T
AU  - Okanoue T
FAU - Kashima, K
AU  - Kashima K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Humans
MH  - Iron Overload/*etiology/pathology
MH  - Liver/*pathology
MH  - Liver Cirrhosis/*diagnosis/*etiology/pathology
MH  - Male
MH  - *Transfusion Reaction
EDAT- 1998/10/17 00:00
MHDA- 1998/10/17 00:01
CRDT- 1998/10/17 00:00
PHST- 1998/10/17 00:00 [pubmed]
PHST- 1998/10/17 00:01 [medline]
PHST- 1998/10/17 00:00 [entrez]
AID - 10.1007/s005350050168 [doi]
PST - ppublish
SO  - J Gastroenterol. 1998 Oct;33(5):751-4. doi: 10.1007/s005350050168.