PMID- 9774977
OWN - NLM
STAT- MEDLINE
DCOM- 19981102
LR  - 20220317
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 2
IP  - 3
DP  - 1998 Sep
TI  - ASK1 is essential for JNK/SAPK activation by TRAF2.
PG  - 389-95
AB  - Tumor necrosis factor (TNF)-induced activation of the c-jun N-terminal kinase 
      (JNK, also known as SAPK; stress-activated protein kinase) requires TNF 
      receptor-associated factor 2 (TRAF2). The apoptosis signal-regulating kinase 1 
      (ASK1) is activated by TNF and stimulates JNK activation. Here we show that ASK1 
      interacts with members of the TRAF family and is activated by TRAF2, TRAF5, and 
      TRAF6 overexpression. A truncated derivative of TRAF2, which inhibits JNK 
      activation by TNF, blocks TNF-induced ASK1 activation. A catalytically inactive 
      mutant of ASK1 is a dominant-negative inhibitor of TNF- and TRAF2-induced JNK 
      activation. In untransfected mammalian cells, ASK1 rapidly associates with TRAF2 
      in a TNF-dependent manner. Thus, ASK1 is a mediator of TRAF2-induced JNK 
      activation.
FAU - Nishitoh, H
AU  - Nishitoh H
AD  - Department of Biochemistry, Cancer Institute, Tokyo, Japan.
FAU - Saitoh, M
AU  - Saitoh M
FAU - Mochida, Y
AU  - Mochida Y
FAU - Takeda, K
AU  - Takeda K
FAU - Nakano, H
AU  - Nakano H
FAU - Rothe, M
AU  - Rothe M
FAU - Miyazono, K
AU  - Miyazono K
FAU - Ichijo, H
AU  - Ichijo H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Proteins)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (TNF Receptor-Associated Factor 5)
RN  - 0 (TNF Receptor-Associated Factor 6)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Cell Line
MH  - Enzyme Activation
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases
MH  - MAP Kinase Kinase Kinases
MH  - Mammals
MH  - *Mitogen-Activated Protein Kinases
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Proteins/genetics/*metabolism
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Recombinant Proteins/metabolism
MH  - Signal Transduction
MH  - TNF Receptor-Associated Factor 2
MH  - TNF Receptor-Associated Factor 5
MH  - TNF Receptor-Associated Factor 6
MH  - Transfection
EDAT- 1998/10/17 00:00
MHDA- 1998/10/17 00:01
CRDT- 1998/10/17 00:00
PHST- 1998/10/17 00:00 [pubmed]
PHST- 1998/10/17 00:01 [medline]
PHST- 1998/10/17 00:00 [entrez]
AID - S1097-2765(00)80283-X [pii]
AID - 10.1016/s1097-2765(00)80283-x [doi]
PST - ppublish
SO  - Mol Cell. 1998 Sep;2(3):389-95. doi: 10.1016/s1097-2765(00)80283-x.