PMID- 9777590
OWN - NLM
STAT- MEDLINE
DCOM- 19981208
LR  - 20190905
IS  - 0022-3484 (Print)
IS  - 0022-3484 (Linking)
VI  - 33
IP  - 5
DP  - 1998 Jul
TI  - Elastic modulus, permeation time and swelling ratio of a new porcine dermal 
      collagen membrane.
PG  - 243-8
AB  - The goal of a single step therapy has been an important consideration in the 
      development of guided tissue regeneration devices. It would spare the patient 
      from the need for repeated surgery and eliminate many problems associated with a 
      non-resorbable barrier. Animal studies of a collagen membrane extracted from 
      porcine dermis (PDCM), as conditioned by different concentrations of 
      glutaraldehyde (GA), have shown it to be biocompatible and biodegradable (up to 9 
      wk). This in vitro study further investigated the physical properties of this 
      membrane. A PDCM modified and cross-linked with various concentrations (0.01%, 
      0.05% and 3.00%) of GA was used. A similar control series was not conditioned. At 
      least 4 specimens for each experimental condition were prepared. The elastic 
      modulus (EM) was measured by a universal testing machine. In the permeability 
      test, Al2O3 particles of different sizes (5-23 microns) were mixed with normal 
      saline to make 5 v/v% suspension and the time needed for collecting 7.5 ml of the 
      filtered suspension from 10 ml suspension was recorded. Swelling ratio (gamma) 
      was also measured according to gamma = 1/Vf (volume fraction). Data were analysed 
      using ANOVA and Tukey's LSD test. The EM (40.8 +/- 3.8 gf/mm2) for the GA 
      conditioned membranes showed no significant difference but was greater (p < 0.05) 
      than that of the control. There was a significant increase (100-300%) in the 
      permeation time with GA concentration (control 0.168 vs. 3% GA 0.100). The 
      results suggest that the physical properties of the GA conditioned PDCM 
      (especially in 3%) may fit the clinical requirements of membrane materials used 
      in guided tissue regeneration techniques.
FAU - Lu, H K
AU  - Lu HK
AD  - School of Dentistry and Graduate Institute of Oral Rehabilitation, Taipei Medical 
      College, Taiwan, Republic of China.
FAU - Lee, S Y
AU  - Lee SY
FAU - Lin, F P
AU  - Lin FP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontal Res
JT  - Journal of periodontal research
JID - 0055107
RN  - 0 (Biocompatible Materials)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Membranes, Artificial)
RN  - 9007-34-5 (Collagen)
RN  - LMI26O6933 (Aluminum Oxide)
RN  - T3C89M417N (Glutaral)
SB  - IM
MH  - Aluminum Oxide/chemistry
MH  - Analysis of Variance
MH  - Animals
MH  - Biocompatible Materials/chemistry
MH  - Biodegradation, Environmental
MH  - Chemical Phenomena
MH  - Chemistry, Physical
MH  - Collagen/*chemistry
MH  - Cross-Linking Reagents/chemistry
MH  - Elasticity
MH  - Equipment Design
MH  - Glutaral/chemistry
MH  - Guided Tissue Regeneration/instrumentation
MH  - *Membranes, Artificial
MH  - Permeability
MH  - Skin
MH  - Stress, Mechanical
MH  - Swine
EDAT- 1998/10/20 00:00
MHDA- 1998/10/20 00:01
CRDT- 1998/10/20 00:00
PHST- 1998/10/20 00:00 [pubmed]
PHST- 1998/10/20 00:01 [medline]
PHST- 1998/10/20 00:00 [entrez]
AID - 10.1111/j.1600-0765.1998.tb02196.x [doi]
PST - ppublish
SO  - J Periodontal Res. 1998 Jul;33(5):243-8. doi: 10.1111/j.1600-0765.1998.tb02196.x.