PMID- 9780978
OWN - NLM
STAT- MEDLINE
DCOM- 19981105
LR  - 20041117
IS  - 0039-6060 (Print)
IS  - 0039-6060 (Linking)
VI  - 124
IP  - 4
DP  - 1998 Oct
TI  - Living unrelated renal donation: the University of Wisconsin experience.
PG  - 604-10; discussion 610-1
AB  - BACKGROUND: Living unrelated renal donation (LURD) has the potential to reduce 
      the current waiting list significantly for kidney transplantation. The purpose of 
      this study was to examine the long-term results of 150 LURDs performed at our 
      center during a 16-year period. METHODS: From Dec 23, 1981, to Feb 13, 1998, 150 
      LURDs, 219 human leukocyte antigen (HLA)-identical, 577 haploidentical, and 1789 
      cadaveric kidney transplant procedures were performed. Surgical complications, 
      rejection episodes, infectious complications, and the cause of graft loss and 
      death were examined. Ten-year patient and graft survival rates between groups 
      were compared. RESULTS: Fourteen surgical complications including lymphocele (n = 
      7), ureteral stricture (n = 4), and ureteral leak (n = 3) were seen. 
      Seventy-eight patients (52%) had 123 rejection episodes and 66 patients (44%) had 
      1 or more infections. Thirty-six allografts were lost and 25 deaths occurred. 
      Patient survival rates at 10 years for HLA-identical, haploidentical, LURD, and 
      cadaveric transplant procedures were 86%, 82%, 63%, and 64%, respectively. 
      Allograft survival rates at 10 years for HLA-identical, haploidentical, LURD, and 
      cadaver transplant procedures were 75%, 59%, 56%, and 44%, respectively. 
      CONCLUSIONS: Long-term LURD allograft survival rates are lower than those for 
      HLA-identical but equivalent to those of haploidentical and better than those of 
      cadaveric kidney transplantations. Spousal and nonspousal LURDs should be 
      actively encouraged to help alleviate the current donor kidney shortage.
FAU - D'Alessandro, A M
AU  - D'Alessandro AM
AD  - Department of Surgery, University of Wisconsin Medical School, Madison, USA.
FAU - Pirsch, J D
AU  - Pirsch JD
FAU - Knechtle, S J
AU  - Knechtle SJ
FAU - Odorico, J S
AU  - Odorico JS
FAU - Van der Werf, W J
AU  - Van der Werf WJ
FAU - Collins, B H
AU  - Collins BH
FAU - Becker, Y T
AU  - Becker YT
FAU - Kalayoglu, M
AU  - Kalayoglu M
FAU - Armbrust, M J
AU  - Armbrust MJ
FAU - Sollinger, H W
AU  - Sollinger HW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cadaver
MH  - Female
MH  - Graft Rejection
MH  - Graft Survival
MH  - HLA Antigens/analysis
MH  - Humans
MH  - *Kidney Transplantation/adverse effects/mortality
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Survival Rate
EDAT- 1998/10/22 00:00
MHDA- 1998/10/22 00:01
CRDT- 1998/10/22 00:00
PHST- 1998/10/22 00:00 [pubmed]
PHST- 1998/10/22 00:01 [medline]
PHST- 1998/10/22 00:00 [entrez]
AID - S0039-6060(98)00317-1 [pii]
AID - 10.1067/msy.1998.91482 [doi]
PST - ppublish
SO  - Surgery. 1998 Oct;124(4):604-10; discussion 610-1. doi: 10.1067/msy.1998.91482.