PMID- 9782316
OWN - NLM
STAT- MEDLINE
DCOM- 19990113
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 440
DP  - 1998
TI  - In vivo and in vitro interferon (IFN) studies with the porcine reproductive and 
      respiratory syndrome virus (PRRSV).
PG  - 461-7
AB  - Some of the interactions between the porcine reproductive and respiratory 
      syndrome virus (PRRSV) and the porcine interferon-alpha (IFN-alpha) system were 
      studied. In a first experiment, it was shown that pretreatment of primary porcine 
      alveolar macrophages (AMs) with recombinant porcine (rPo) IFN-alpha 1 resulted in 
      significant reductions of PRRSV yield and numbers of antigen expressing cells. In 
      a second experiment, sensitivity of PRRSV to IFN-alpha was confirmed in vivo. In 
      pigs inoculated with porcine respiratory coronavirus (PRCV)--a potent inducer of 
      endogenous IFN-alpha in the lungs of pigs--followed 2 days later by PRRSV--lung 
      PRRSV titers were 1.7 to 2.9 log10 TCID50 reduced compared to those in singly 
      PRRSV inoculated pigs. It was concluded therefore that PRRSV has a fairly good 
      sensitivity to the antiviral effects of IFN-alpha. A third experiment documented 
      that in vivo PRRSV infection generally does not affect PRCV-induced IFN-alpha 
      production in the lungs of pigs. In addition, it was shown that the IFN-inducing 
      capacity of PRRSV is at least 159 times lower than that of PRCV. This finding 
      suggests that cells other than AMs may be responsible for IFN production in the 
      lungs of pigs.
FAU - Buddaert, W
AU  - Buddaert W
AD  - Laboratory of Veterinary Virology, Faculty of Veterinary Medicine, University of 
      Gent, Merelbeke, Belgium.
FAU - Van Reeth, K
AU  - Van Reeth K
FAU - Pensaert, M
AU  - Pensaert M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Interferon Type I)
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Interferon Type I/pharmacology
MH  - Interferon-alpha/*biosynthesis
MH  - Lung/immunology/pathology
MH  - Macrophages, Alveolar/drug effects/*immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/pathology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Recombinant Proteins
MH  - Swine
EDAT- 1998/10/23 00:00
MHDA- 1998/10/23 00:01
CRDT- 1998/10/23 00:00
PHST- 1998/10/23 00:00 [pubmed]
PHST- 1998/10/23 00:01 [medline]
PHST- 1998/10/23 00:00 [entrez]
AID - 10.1007/978-1-4615-5331-1_59 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 1998;440:461-7. doi: 10.1007/978-1-4615-5331-1_59.