PMID- 9785267
OWN - NLM
STAT- MEDLINE
DCOM- 19981230
LR  - 20191102
IS  - 0885-579X (Print)
IS  - 0885-579X (Linking)
VI  - 12
IP  - 3
DP  - 1998 Fall
TI  - Special feature: family-genetic research strategies for personality disorders.
PG  - 262-76
AB  - Personality disorders (PD) might be considered as extremes of personality 
      dimensions varying in the general population or as attenuated variants of major 
      psychiatric disorders. Both personality variation and major psychiatric disorders 
      have been shown in twin and adoption studies, to be influenced by genes. Hence, 
      it is likely that personality disorders are also under genetic control. However, 
      direct evidence for influential familial and genetic factors is scarce. Various 
      research strategies in this area are described and current evidence is reported. 
      Gene-oriented approaches seem to be particularly promising. This strategy is 
      illustrated for personality disorders in obligate carriers of mutations in the 
      fragile-X gene.
FAU - Maier, W
AU  - Maier W
AD  - Department of Psychiatry, University of Bonn, FRG. w.maier@uni-bonn.de
FAU - Franke, P
AU  - Franke P
FAU - Hawellek, B
AU  - Hawellek B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Pers Disord
JT  - Journal of personality disorders
JID - 8710838
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Personality Disorders/diagnosis/*genetics/psychology
MH  - Point Mutation/genetics
RF  - 66
EDAT- 1998/10/24 00:00
MHDA- 1998/10/24 00:01
CRDT- 1998/10/24 00:00
PHST- 1998/10/24 00:00 [pubmed]
PHST- 1998/10/24 00:01 [medline]
PHST- 1998/10/24 00:00 [entrez]
AID - 10.1521/pedi.1998.12.3.262 [doi]
PST - ppublish
SO  - J Pers Disord. 1998 Fall;12(3):262-76. doi: 10.1521/pedi.1998.12.3.262.