PMID- 9786409
OWN - NLM
STAT- MEDLINE
DCOM- 19981223
LR  - 20220330
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 400
IP  - 4
DP  - 1998 Nov 2
TI  - Adult olfactory epithelium contains multipotent progenitors that give rise to 
      neurons and non-neural cells.
PG  - 469-86
AB  - We have infused replication-incompetent retroviral vectors into the nasal cavity 
      of adult rats 1 day after exposure to the olfactotoxic gas methyl bromide (MeBr) 
      to assess the lineage relationships of cells in the regenerating olfactory 
      epithelium. The vast majority of the retrovirus-labeled clones fall into three 
      broad categories: clones that invariably contain globose basal cells (GBCs) 
      and/or neurons, clones that always include cells in the ducts of Bowman's glands, 
      and clones that are composed of sustentacular cells only. Many of the GBC-related 
      clones contain sustentacular cells and horizontal basal cells as well. Most of 
      the duct-related clones contain gland cells, and some also include sustentacular 
      cells. Thus, the destruction of both neurons and non-neuronal cells that is 
      caused by MeBr activates two distinct types of multipotent cells. The multipotent 
      progenitor that gives rise to neurons and non-neuronal cells is a basal cell, 
      whereas the progenitor that gives rise to duct, gland, and sustentacular cells 
      resides within the ducts, based on the pattern of sparing after lesion and the 
      analysis of early regeneration by using cell type-specific markers. We conclude 
      that the balance between multipotency and selective neuropotency, which is 
      characteristic of globose basal cells in the normal olfactory epithelium, is 
      determined by which cell types have been depleted and need to be replenished 
      rapidly.
FAU - Huard, J M
AU  - Huard JM
AD  - Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse, New 
      York 13210, USA.
FAU - Youngentob, S L
AU  - Youngentob SL
FAU - Goldstein, B J
AU  - Goldstein BJ
FAU - Luskin, M B
AU  - Luskin MB
FAU - Schwob, J E
AU  - Schwob JE
LA  - eng
GR  - K04 DC00080/DC/NIDCD NIH HHS/United States
GR  - P01 DC00220/DC/NIDCD NIH HHS/United States
GR  - R01DC02167/DC/NIDCD NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Genetic Vectors
MH  - Neurons/*cytology
MH  - Olfactory Mucosa/*cytology
MH  - Rats/*anatomy & histology
MH  - Rats, Sprague-Dawley
MH  - Retroviridae/genetics
MH  - Stem Cells/*cytology
EDAT- 1998/10/24 02:15
MHDA- 2000/06/20 09:00
CRDT- 1998/10/24 02:15
PHST- 1998/10/24 02:15 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/10/24 02:15 [entrez]
AID - 10.1002/(SICI)1096-9861(19981102)400:4<469::AID-CNE3>3.0.CO;2-8 [pii]
PST - ppublish
SO  - J Comp Neurol. 1998 Nov 2;400(4):469-86.