PMID- 9786846
OWN - NLM
STAT- MEDLINE
DCOM- 19981201
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 273
IP  - 44
DP  - 1998 Oct 30
TI  - Steroid receptor coactivator-1 interacts with serum response factor and 
      coactivates serum response element-mediated transactivations.
PG  - 28564-7
AB  - Steroid receptor coactivator-1 (SRC-1) specifically bound to serum response 
      factor (SRF), as demonstrated by glutathione S-transferase pull down assays, and 
      the yeast and mammalian two-hybrid tests. In mammalian cells, SRC-1 potentiated 
      serum response element (SRE)-mediated transactivations in a dose-dependent 
      manner. Coexpression of p300 synergistically enhanced this SRC-1-potentiated 
      level of transactivations, consistent with the recent finding (Ramirez, S., Ali, 
      S. A. S., Robin, P., Trouche, D., and Harel-Bellan, A. (1997) J. Biol. Chem. 272, 
      31016-31021) in which the p300 homologue CREB-binding protein was shown to be a 
      transcription coactivator of SRF. Thus, we concluded that at least two distinct 
      classes of coactivator molecules may cooperate to regulate SRF-dependent 
      transactivations in vivo.
FAU - Kim, H J
AU  - Kim HJ
AD  - College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea.
FAU - Kim, J H
AU  - Kim JH
FAU - Lee, J W
AU  - Lee JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Serum Response Factor)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (NCOA1 protein, human)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
MH  - DNA-Binding Proteins/*metabolism
MH  - HeLa Cells
MH  - Histone Acetyltransferases
MH  - Humans
MH  - Nuclear Proteins/*metabolism
MH  - Nuclear Receptor Coactivator 1
MH  - Protein Binding
MH  - Serum Response Factor
MH  - Transcription Factors/*metabolism
MH  - *Transcriptional Activation
MH  - Transfection
EDAT- 1998/10/24 00:00
MHDA- 1998/10/24 00:01
CRDT- 1998/10/24 00:00
PHST- 1998/10/24 00:00 [pubmed]
PHST- 1998/10/24 00:01 [medline]
PHST- 1998/10/24 00:00 [entrez]
AID - S0021-9258(19)59426-1 [pii]
AID - 10.1074/jbc.273.44.28564 [doi]
PST - ppublish
SO  - J Biol Chem. 1998 Oct 30;273(44):28564-7. doi: 10.1074/jbc.273.44.28564.