PMID- 9789454
OWN - NLM
STAT- MEDLINE
DCOM- 19981215
LR  - 20080610
IS  - 1661-8157 (Print)
IS  - 1661-8157 (Linking)
VI  - 87
IP  - 38
DP  - 1998 Sep 16
TI  - [Reflux disease: drug treatment].
PG  - 1222-5
AB  - Reflux disease of the esophagus is characterized by a high prevalence and by high 
      relapse rates. Upper endoscopy is the key procedure for diagnosis of the disease 
      as well as for follow up, since treatment is determined by disease intensity as 
      judged by endoscopy. High activity of disease is associated with an increased 
      risk of complications, in the worst case development of adenocarcinoma. General 
      recommandations (weight reduction, change of eating habits) constitute the start 
      of each treatment regimen, and may add to improvement of symptoms, sometimes in 
      combination with antacids. Prokinetics and H2-receptor antagonists are effective 
      in mild reflux disease (grade O, I), but even in these situations proton pump 
      inhibitors (PPI) exhibit better relief of symptoms and more rapid healing. PPI 
      are the drugs of first choice for higher disease activity, often in larger than 
      standard daily doses. The treatment period for acute disease may be as long as 12 
      weeks. Long term prophylaxis is only effective with PPIs, mostly in the standard 
      daily dose. Duration of long term treatment is determined by disease activity and 
      tendency of the lesions to heal. Today, in case of treatment failure and of high 
      grade lesions antireflux surgery is increasingly being reconsidered, particularly 
      since minimally invasive methods are available.
FAU - Gugler, R
AU  - Gugler R
AD  - Stadtisches Klinikum, I. Medizinische Klinik, Karlsruhe.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Refluxkrankheit: Medikamentose Therapie.
PL  - Switzerland
TA  - Praxis (Bern 1994)
JT  - Praxis
JID - 101468093
SB  - IM
MH  - Gastroesophageal Reflux/diagnosis/*drug therapy
MH  - Humans
RF  - 13
EDAT- 1998/10/28 00:00
MHDA- 1998/10/28 00:01
CRDT- 1998/10/28 00:00
PHST- 1998/10/28 00:00 [pubmed]
PHST- 1998/10/28 00:01 [medline]
PHST- 1998/10/28 00:00 [entrez]
PST - ppublish
SO  - Praxis (Bern 1994). 1998 Sep 16;87(38):1222-5.