PMID- 9792021
OWN - NLM
STAT- MEDLINE
DCOM- 19990105
LR  - 20191111
IS  - 0723-5003 (Print)
IS  - 0723-5003 (Linking)
VI  - 93
IP  - 9
DP  - 1998 Sep 15
TI  - [Multiple endocrine neoplasia associated with multiple lipomas].
PG  - 546-9
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN-1) is characterized by 
      tumors of the parathyroids, the neuroendocrine pancreas-duodenum and the anterior 
      pituitary, but shows also a wide clinical variety of other symptoms. CASE REPORT: 
      We present a case of a 68-year-old woman with a 18 year history of MEN-1 
      consisting of gastrinoma and primary hyperparathyroidism. Beside these typical 
      symptoms, the patient suffered from thyroid adenoma, malignant kidney tumor and 
      multiple subcutaneous lipomas. RESULT: While the number of autopsies declined 
      from 113 in 1977 to 66 in 1984, the number of diagnostic techniques used 
      increased continuously (94, 107, 118 and 140, amounting to 0.83, 1.34, 1.76 and 
      2.12 per patient). The premortal detection of abdominal abnormalities increased 
      globally from 16.8 to 32.5%. This increase was largely due to better diagnosis of 
      liver and gallbladder abnormalities which were in most cases of little relevance. 
      CONCLUSION: Whether these non-endocrine tumors are associated to MEN-1 is unclear 
      and has to be tested by examining the chromosomal regions 11q13 and 11q24/25 of 
      the tumors sample, in which the possible MEN-1 involved tumor suppressor genes 
      are located.
FAU - Hofmann, M
AU  - Hofmann M
AD  - Abteilung Endokrinologie und Stoffwechsel, Medizinische Universitatsklinik 
      Heidelberg.
FAU - Schilling, T
AU  - Schilling T
FAU - Heilmann, P
AU  - Heilmann P
FAU - Haisken, O
AU  - Haisken O
FAU - Wuster, C
AU  - Wuster C
FAU - Brandi, M L
AU  - Brandi ML
FAU - Ziegler, R
AU  - Ziegler R
FAU - Nawroth, P P
AU  - Nawroth PP
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Multiple endokrine Neoplasie assoziiert mit multiplen Lipomen.
PL  - Germany
TA  - Med Klin (Munich)
JT  - Medizinische Klinik (Munich, Germany : 1983)
JID - 8303501
SB  - IM
MH  - Aged
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11
MH  - Female
MH  - Genes, Tumor Suppressor/genetics
MH  - Humans
MH  - Lipoma/diagnosis/*genetics
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics
MH  - Neoplasms, Multiple Primary/diagnosis/*genetics
MH  - Pedigree
MH  - Soft Tissue Neoplasms/diagnosis/*genetics
EDAT- 1998/10/29 03:03
MHDA- 2000/03/22 09:00
CRDT- 1998/10/29 03:03
PHST- 1998/10/29 03:03 [pubmed]
PHST- 2000/03/22 09:00 [medline]
PHST- 1998/10/29 03:03 [entrez]
AID - 10.1007/BF03042664 [doi]
PST - ppublish
SO  - Med Klin (Munich). 1998 Sep 15;93(9):546-9. doi: 10.1007/BF03042664.