PMID- 9792200
OWN - NLM
STAT- MEDLINE
DCOM- 19990105
LR  - 20190822
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 51
IP  - 3
DP  - 1998 Sep
TI  - Expanded (CAG)n, (CGG)n and (GAA)n trinucleotide repeat microsatellites, and 
      mutant purine synthesis and pigmentation genes cause schizophrenia and autism.
PG  - 223-33
AB  - Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause 
      schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia 
      type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions 
      of (CGG)n and (GAA)n trinucleotide repeat stretches at fragile X syndrome 
      (FRAXA), and the recessive Friedreich's ataxia (FA). Dominant ataxia genes may 
      cause schizophrenia and recessive ataxia genes may cause autism. Syndromes with 
      autism show purine synthesis defects (PSDs) and/or pigmentation defects (PDs). 
      Autism is caused by very lengthy expansions of (CAG)n, (CGG)n and (GAA)n repeats, 
      while schizophrenia results from much smaller (CAG)n and (CGG)n repeat 
      expansions.
FAU - Fischer, K M
AU  - Fischer KM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Purines)
SB  - IM
MH  - Animals
MH  - Autistic Disorder/*genetics
MH  - Fragile X Syndrome/genetics
MH  - Friedreich Ataxia/genetics
MH  - Genes, Dominant
MH  - Humans
MH  - *Models, Genetic
MH  - Pigmentation/*genetics
MH  - Purines/*biosynthesis
MH  - Schizophrenia/*genetics
MH  - Trinucleotide Repeat Expansion/*genetics
EDAT- 1998/10/29 00:00
MHDA- 1998/10/29 00:01
CRDT- 1998/10/29 00:00
PHST- 1998/10/29 00:00 [pubmed]
PHST- 1998/10/29 00:01 [medline]
PHST- 1998/10/29 00:00 [entrez]
AID - S0306-9877(98)90080-9 [pii]
AID - 10.1016/s0306-9877(98)90080-9 [doi]
PST - ppublish
SO  - Med Hypotheses. 1998 Sep;51(3):223-33. doi: 10.1016/s0306-9877(98)90080-9.